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5 Cards in this Set
- Front
- Back
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What are the main non-NSAID anti-inflammatories used in veterinary medicine? |
Dietary fatty acids Glucosamine Chondroitin Polysulfated glycosaminoglycans: Pentosan polysulfate Hyaluronate |
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What is the MOA of dietary fatty acids?
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Competitive inhibition of inflammation by providing a substrate for phospholipid diesterase to act on thus preventing the COX linked production in inflammatory mediators. |
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What is the MOA of glucosamine? |
Provides building blocks for proteoglycan which comprises the cartilage Very poor bioavailablity due to 1st pass metabolism. |
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What is the MOA of chondritin? |
Provides building blocks for proteoglycan which comprises the cartilage Rapidly absorbed from gut. |
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What is the MOA of the polysulfated glycosaminoglycans? |
Stimulates fibroblasts to produce hyaluronic acid which help improve joint fluid viscosity Inhibits inflammatory mediators Improves subchondral blood flow |
