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44 Cards in this Set
- Front
- Back
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Types of Non-Neoplastic Orthopedic Pathology?
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Congenital/Hereditary
Acquired Infectious Joints |
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Who are the Congenital/Hereditary Non-Neoplastic Orthopedic Pathologies?
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Achondroplasia
Osteogenesis Imperfecta Osteopetrosis |
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Who are the Acquired Non-Neoplastic Orthopedic Pathologies?
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Osteoporosis
Osteomalacia Paget's |
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Who are the Infectious Non-Neoplastic Orthopedic Pathologies?
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Pyogenic vs. Tuberculous
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Who are the Non-Neoplastic Orthopedic Pathologies involving joints?
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OA
RA Gouty A Infectious A |
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ACHONDROPLASIA
etiology? |
Auto Dom
Mutation of fibroblastic growth factor receptor 3 (FGFR3) on short arm of 4 Inhibits normal prolif of cartilage-->failure to form normal epiphyseal cartilage |
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ACHONDROPLASIA
bone findings? |
short proximal extremities (e.g. humorous)
bowed legs |
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OSTEOGENESIS IMPERFECTA
Etiology? |
Auto Dom disorder of delayed maturation of bones
Mutation in gene for Type 1 collagen Deletions on 17 or 7 |
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OI
sx's? |
Brittle Bones
Blue Sclerae Hearing Loss |
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Osteopetrosis
etiology? |
Auto Recessive (or dom) modeling disorder
Failed Osteoclastic bone resorption-->disorganized dense bone in marrow |
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Osteopetrosis
aka? |
marble bone disease
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Osteopetrosis
sx's? |
weakness
fractures |
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What is the most common Acquired Metabolic Bone Disease?
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Osteoporosis
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OSTEOPOROSIS
Pathogenesis? |
Increased Osteoclast Activity
Decreased Osteoblast Activity Thin Trabeculae |
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OSTEOPOROSIS
typical patient? |
Older
Post-menopausal Fractures |
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OSTEOPOROSIS
types of common fractures |
Vertebral Collapse
Neck of Femur Wrists |
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OSTEOMALACIA
pathogenesis |
Failure of Bone Mineralization (inc osteoid)
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OSTEOMALACIA
most common etiology? |
Vit D Def
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OSTEOMALACIA
Skeletal Sx's |
Leg Bowing
Distortion of Skull Enlarged Costochondral Jxn (pigeon breast) |
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OSTEOMALACIA
trabeculae? |
Thicker than normal secondary to thicker osteoid
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PAGET'S DISEASE
pathogenesis? |
Excessive Resorption of Bone
Large abnormal osteoclasts Severe Osteoclastic erosion Vigorous/Uncoordinated Osteoblastic Response -->Distorted Bone Architecture |
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PAGET'S DISEASE
etiology? |
Possibly paramyxovirus
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PAGET'S DISEASE
sx's? |
Fractures (bone bulk is up, but weak)
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PAGET'S DISEASE
increased incidence of? |
osteosarcoma
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OSTEOMYELITIS
Pathogenesis? |
Bacterial Infection of Bone
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OSTEOMYELITIS
types? |
Pyogenic
Tuberculous |
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PYOGENIC OSTEOMYELITIS
route of infection? |
Hematogenous
Direct Penetration |
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PYOGENIC OSTEOMYELITIS
which bones involved? |
Long Bones in Kids
Vertebrae in Adults |
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PYOGENIC OSTEOMYELITIS
typical invaders? |
Staph Aureus
Salmonella (in sickle cell pts) |
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TUBERCULOUS OSTEOMYELITIS
Involvement? |
Long Bones (starts in synovium)
Vertebrae (pott's disease) |
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OSTEOMYELITIS
associations? |
Ulcerated Skin
Squamous Carcinoma of Sinus |
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Complication w/ Pott's?
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Vertebral Collapse, but can be uneven leading to SC impingment
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Pathogenesis of OA
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OA: Articular Cartilage Degeneration
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Pathogenesis of RA?
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Proliferation of Synovium
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Pathogenesis of Gouty A
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Crystal Induced
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Pathogenesis of Infectious A
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Organism Induced
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Which Joints are involved w/ OA?
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Weight Bearing
DIP/PIP |
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Which Joints are involved w/ RA?
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PIP
FEET |
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Which Joints are involved w/ Gouty A
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Great Toe
Ankle Heel Wrist |
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Which Joints are involved w/ Infectious A?
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Variable
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Pathology of OA?
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Erosion
Eburnation |
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Pathology of RA?
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Pannus
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Pathology of Gouty A?
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Uric Acid Deposits
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Pathology of Infectious A?
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Pus
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