Non-Neoplastic Disorders Of Wbcs

Front 1

Which cell type is described:
10-12 micrometers, nucleus with two to four lobes, cytoplasmic granules.
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 1

A. Neutrophil

Front 2

Which cell type is described:
11-14 micrometer, bilobed nucleus, large organe-red cytoplasmic granules
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 2

B. Eosinophil

Front 3

Which cell type is described:
10-12 micrometers, bilobed with indistinct nuclei, large blue-purple granules. Releases histamine that promotes inflammation and heparin, that prevents clot formation.
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 3

C. Basophil

Front 4

Which cell type is described:
6-14 micrometers, round nucleus, scant cytoplasm. some produce antibodies and other mediate humoral immunity
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 4

D. Lymphocyte

Front 5

Which cell type is described:
12-20 micrometers, round to kidney shaped nuclei, abundant cytoplasm
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 5

E. Monocyte

Front 6

Which cell type is described:
This has a function of releasing chemicals that regulate inflammation, kills parasitic worms, role in allergies.
A. Neutrophil
B. Eosinophil
C. Basophil
D. Lymphocyte
E. Monocyte

Back 6

B. Eosinophil

Front 7

Clinical Feature: occulocutaneous albinisms, neuropathy, infections, tendency to develop malignancies, albinism and infections ininfancy
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 7

A. Chediak Higashi syndrome

Front 8

Laboratory findings include: abnormal leukocyte granules, poor neutrophil chemotaxis decreased natural killer cell activity. Mutation in LYST, encoding a cytoplasmic protein involved in protein transport.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 8

A. Chediak Higashi syndrome

Front 9

Clinical features: Recurrent bacterial infections with catalase-positive organisms, granulomas that may obstruct genitourinary tract, most patients are diagnosed < 1 year of age but few are not until early adolesence.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 9

B. Chronic granulomatous disease

Front 10

Laboratory findings include lack of oxygen radical production and poor bacterial killing.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 10

B. Chronic granulomatous disease

Front 11

Clinical features: most are asymptomatic. But if patient has diabetes mellitus, recurrent fungal or bacterial infections are common.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 11

C. Myeloperoxidase deficiency

Front 12

Clinical features include: delayed umbilical cord separation, gingivitis, bacterial infections (Gram neg enteric bact, S. aureus, candida, aspergillus). Infections usually begin in infancy.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 12

D. Leukocyte adhesion deficiency

Front 13

Lab findings: Leukocytosis, lack of surface adhesion receptors, decreased neutrpohil chemotaxis, decreased natural killer cell activity. Mutation in CD 18 gene or genes involved in carbohydrate fucosylation.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 13

D. Leukocyte adhesion deficiency

Front 14

Clinical features: Eczema, respiratory infections, coarse facial features, osteoporosis, skin rash note in infancy but infections may start later.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 14

E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Front 15

Due to abnormality in CD18.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 15

D. Leukocyte adhesion deficiency

Front 16

This, along with G6PD deficiency, is a disorder of intracellular killing due to defect in NADPH oxidase system.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 16

B. Chronic granulomatous disease

Front 17

This is a defect in neutrophil granule formation or function. This is the MOST COMMON DISORDER OF NEUTROPHIL GRANULES.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 17

C. Myeloperoxidase deficiency

Front 18

This is an autosomal recessive disorder of all lysosomal granule containing cells. Peripheral blood smear exam reveals characteristic giant cytoplasmic grnules in neutrophils, formed from the fusion of lysosomes and endosomes. Neutrophil chemotaxis and intracellular killing is impaired.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 18

A. Chediak Higashi syndrome

Front 19

This is a primary immunodeficiency most common in fair skinned females with red hair. Characterized by a recurrent pruritic dermatitis with staph abscesses, sinusitis, otitis media and recurrent pneumonia.
A. Chediak Higashi syndrome
B. Chronic granulomatous disease
C. Myeloperoxidase deficiency
D. Leukocyte adhesion deficiency
E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

Back 19

E. Hyper IgE syndrome (Job Syndrome, Buckley Syndrome)

main lab findings is midl eosinophilia, serum levels of IgE markedly elevated , and abnormalities in T and B lymphocyte function.