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30 Cards in this Set
- Front
- Back
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UV radiation damage
precursor to SCC rough scaling papule or patch cutaneous horn |
actinic keratosis
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basal layer atypia
intercellular bridges hyper/parakeratosis |
AK
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erythematous, scaly papules/plaques
found on palpation sun-exposed skin |
AK
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how is AK treated?
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5-FU; skin will become red and inflamed
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which is the most common type of skin cancer?
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basal cell
(2nd is SCC) |
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male >60yo
sun, arsenic, soot, XR exposure, HPV = risk factors |
SCC
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sharply defined red scaling plaque
head & neck, esp lower lip invasive, central hyperkeratotic scale |
SCC
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all levels of epidermis involved
atypical cels enlarged hyperchrom. nuclei intercell bridges, keratin, dyskertatotic cells |
SCC
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what is the DDx for SCC?
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keratoacanthoma
hypertrophic actinic keratosis, wart, basal cell ca, seborrheic keratosis, bowen's ds |
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rapidly growing nodule with central keratin-filled crater
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keratoacanthoma
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lobules of squamous cells
glassy cytoplasm keratinization without granular layer dermal inflamm: lymphocytes, eosinophils |
keratoacanthoma
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what is the MC invasive cancer in humans?
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basal cell carcinoma
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what is the cause of basal cell carcinoma?
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UV radiation
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what mutations are assoc. w/ basal cell carcinoma?
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PTCH (patched gene) & p53
Gorlin Sd germline mutation |
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nodular growth on face, esp nose
pearly papule telangiectasias (dilated subepidermal bv's) central depression, rolled border "rodent ulcer" - w/ crusting |
basal cell carcinoma
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clefting, palisading
bundles of CT stroma w/ mucin |
nodular basal cell carcinoma
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on trunk
scaly, erythematous translucent plaques distant, threadlike border |
superficial basal cell carcinoma
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multiple tumor lobules attached to epidermis
little penetration to dermis |
superficial basal cell carcinoma
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ivory-white
scar-appearing plaque indistinct border head or neck |
morpheaform BCC
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dense fibrous stroma
elongated strands of tumor cells deep into dermis or SQ NO palisading or clefts |
morpheaform BCC
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brown-to-black hyperpigmentation
lg amount of melanin in tumor cells like nodular BCC |
pigmented BCC
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what are the bad prognostic indicators in BCC?
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>2cm, deep invasion, MORPHEAFORM type
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long, thin, branching anastomosing strands of tumor cells
embedded in fibrous stroma superficial, well-demarcated |
fibroepithelioma of pinkus
uncommon BCC variant |
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firm, sessile to pedunculated papule or nodule w/ smooth or nodule surface
looks like benign fibroma or seborrheic keratosis |
fibroepithelioma of pinkus
uncommon BCC variant |
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rare tumor, head & neck, 65yo pt
firm, solitary, painless rapidly growing pink/blue/red-brown nodule VERY AGGRESSIVE |
merkel cell carcinoma
rare worst ever |
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nodular/diffuse OR trabecular (sheets of cells make nests, cords, trabeculae), OR mix
large, uniform, basophilic cells scant cytoplasm |
merkel cell carcinoma
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(+) neuron-specific enolase
(+) cytokeratin 20 |
merkel cell ca
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cutaneous T-cell lymphoma
trunk usually scaly red brown patches or scaling plaques |
mycosis fungoides
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sezary-lutzner cells
(helpter T's form band-like aggregates w/i superficial dermis, invade epidermis as clusters and single cells) |
mycosis fungoides
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what is sezary sd?
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skin involvement as exfoliative erythroderma w/ assoc leukemia of sezary cells w/ cerebriform nuclei
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