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14 Cards in this Set

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Small lymphocytic lymphoma
-Adults
-B cell
- like CLL with focal mass, low grade
(CLL older adults, lymphadenopathy, hepsplenomegaly, smudge cells, warm autoimmune hemolytic anemia)
Follicular lymphoma
-Adults
-B cells
- 14:18 bcl-2
-most common in adults and difficult to cure
Diffuse large cell lymphoma
-80% older adults 20% children
-B cells(80%) T cells (20%, mature
-agressive but 50% curable
Mantle cell lymphoma
-Adults
-B cells
-(11:14)bcl-1, cyclin D
-CD 5 poor prognosis
Lymphoblastic lymphoma
-most common in Children
-T cells (immature)
-most commonly presents with ALL and mediastinal mass, very aggressive

(ALL children, lymphoblasts and most responsive to therapy- may spread to CNS and testes)
Burkitt's Lymphoma
-Children
-B cells
- c-myc 8:14
-"starry sky"- lymphocytes with macrophages in between
-associated with EBV- endemic: jaw lesion
-pelvis and abdomen- sporadic form
What are the B cell lymphomas?
small lymphocytic
follicular
diffuse large cell (80%)
mantle cell
Burkitt's

ALL EXCEPT LYMPHOBLASTIC LYMPHOMA
What is the MC lymphoma in children?
lymphoblastic lymphoma
what is the MC lymphoma in adults?
follicular lymphoma
what are the three lymphomas with translocations?
-follicular (14:18)bcl-2
-mantle (11:14)bcl-1, cyclin D
-Burkitt's (8:14)c-myc
Acute lymphoblastic leukemia
children
lymphoblasts
most resp to therapy and may spread to CNS and testes
Acute myeloblastic leukemia
Auer rods, myeloblasts, adults
Chronic lymphocytic leukemia
-older adults, lymphadenopathy and hepatosplenmegaly
-few symptoms
-indolent course
-warm autoimmune hemolytic anemia

-similar to small lymphocytic lymphoma
Chronic myelocytic leukemia
-myeloid stem cell proliferation
-increased neutrophils and metamyelocytes
-splenomegaly
-(9:22 philidelphia chromosome bcr-abl)
-low leukocyte alkaline phosphatase (unlike leukemoid reaction)

-may accelerte to AML "blast crisis"