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14 Cards in this Set
- Front
- Back
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Small lymphocytic lymphoma
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-Adults
-B cell - like CLL with focal mass, low grade (CLL older adults, lymphadenopathy, hepsplenomegaly, smudge cells, warm autoimmune hemolytic anemia) |
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Follicular lymphoma
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-Adults
-B cells - 14:18 bcl-2 -most common in adults and difficult to cure |
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Diffuse large cell lymphoma
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-80% older adults 20% children
-B cells(80%) T cells (20%, mature -agressive but 50% curable |
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Mantle cell lymphoma
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-Adults
-B cells -(11:14)bcl-1, cyclin D -CD 5 poor prognosis |
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Lymphoblastic lymphoma
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-most common in Children
-T cells (immature) -most commonly presents with ALL and mediastinal mass, very aggressive (ALL children, lymphoblasts and most responsive to therapy- may spread to CNS and testes) |
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Burkitt's Lymphoma
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-Children
-B cells - c-myc 8:14 -"starry sky"- lymphocytes with macrophages in between -associated with EBV- endemic: jaw lesion -pelvis and abdomen- sporadic form |
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What are the B cell lymphomas?
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small lymphocytic
follicular diffuse large cell (80%) mantle cell Burkitt's ALL EXCEPT LYMPHOBLASTIC LYMPHOMA |
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What is the MC lymphoma in children?
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lymphoblastic lymphoma
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what is the MC lymphoma in adults?
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follicular lymphoma
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what are the three lymphomas with translocations?
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-follicular (14:18)bcl-2
-mantle (11:14)bcl-1, cyclin D -Burkitt's (8:14)c-myc |
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Acute lymphoblastic leukemia
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children
lymphoblasts most resp to therapy and may spread to CNS and testes |
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Acute myeloblastic leukemia
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Auer rods, myeloblasts, adults
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Chronic lymphocytic leukemia
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-older adults, lymphadenopathy and hepatosplenmegaly
-few symptoms -indolent course -warm autoimmune hemolytic anemia -similar to small lymphocytic lymphoma |
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Chronic myelocytic leukemia
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-myeloid stem cell proliferation
-increased neutrophils and metamyelocytes -splenomegaly -(9:22 philidelphia chromosome bcr-abl) -low leukocyte alkaline phosphatase (unlike leukemoid reaction) -may accelerte to AML "blast crisis" |
