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28 Cards in this Set
- Front
- Back
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What proportion of Non-Hodgkin's Lymphoma is B-cell vs T-cell? |
88% B-cell, 12% T-cell |
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Which type of lymphoma involves a defect in the BCL2 gene?
What translocation does it involve? |
Follicular Lymphoma
t(14;18) |
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Which type of lymphoma involves a defect in the cyclinD1 gene?
What translocation does it involve? |
Mantle Cell Lymphoma
t(11;14) |
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Which type of lymphoma involves a defect in the p53 gene?
What translocation does it involve? (3) |
Chronic Lymphoid Leukemia / Small lymphocyte lymphoma
+12, 13q, -17p |
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Which type of lymphoma involves a defect in the MALT1
What translocation does it involve? |
MALT = Mucosa-associated lymphoid tissue lymphoma
t(11;18), trisomy 13 |
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Which type of lymphoma involves a defect in the BCL6?
What translocation does it involve? |
DLBCL = Diffuse Large B-Cell Lymphoma
3q27 |
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Which type of lymphoma involves a defect in the MYC gene?
What translocation does it involve? |
Burkitt's lymphoma
t(8;14) |
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Which type of lymphoma involves a defect in the ALK gene?
What translocation does it involve? |
ALCL = Anaplastic Large Cell Lymphoma
t(2;5) |
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What cell surface markers are found on small lymphocyte lymphoma cells? (4) |
CD19, CD20, CD5, CD23 |
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What characteristics would make for a poor prognosis for SLL? (5) |
- High Stage - CD38+, ZAP 70+ - diffuse marrow involvement - del 11q22-23, 17p13 - Richter Syndrome |
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Describe Follicular Lymphoma. (5) |
- Indolent - Germinal center lymphocytes - Affects middle-aged to older adults - usually high stage - cell-markers: CD19, CD20, CD10, CD23, BCL-2 |
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Describe Mantle Cell Lymphoma. (4) |
- Usually nodal, but may be splenic or G.I. - Affects more men than women - Cell markers: CD19, CD20, CD5, BCL-1 - Lack CD23 |
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Describe Marginal zone lymphoma. (2) |
- Can be splenic, nodal, or MALT - Characteristic monocytoid appearance |
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For what does MALT stand?
With what pathogen is it associated? |
Mucosa-associated Lymphoid Tissue
Helicobacter pylori |
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With what translocation is MALT lymphoma associated if not caused by bacteria? (2) |
t(11;18), t(1;14) |
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What cell surface markers are found on Marginal zone / MALT lymphoma cells?
What cell markers are absent? |
CD19+, CD20+
CD5-, CD10- |
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What cell surface markers define DLBCL? |
CD19, CD20, +/-CD10 |
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With what viruses is DLBCL associated? (2) |
EBV and HHV-8 |
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Describe Primary Mediastinal Large B-cell Lymphoma. (6) |
- Affects young women - Thymic origin - Locally aggressive - Compartmentalizing fibrosis - Cell surface markers: CD45+, CD20+, CD30+ - Lacking: sIG- |
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Describe Burkitt's lymphoma. (6) |
- Very aggressive B-cell lymphoma - Affects kids, immunosuppressed - Extranodal (jaw, G.I., abdominal viscera) - Starry sky appearance - May be associated with EBV (endemic in Africa) - Cell surface markers: CD20+, CD10+ |
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What 3 translocations can cause Burkitt's lymphoma |
t(8;14) IgH/C-Myc
Kappa (2;8)
Lambda (8;22) |
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Describe Extra-Nodal NK/T-cell lymphoma (nasal type). (5) |
- Lethal midline granuloma - Seen in Asia and Central/South America - Has vasculitis like appearance - EBV+, CD3+, CD56+ - Poor prognosis |
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Describe Adult T-Cell Leukemia/lymphoma (6) |
- Seen in Caribbean, Japan, Africa - Neoplasm of mature T4 cells - Caused by HTLV-1 - Presents as rash, hypercalcemia, - Lymphocytosis with flower cells - Aggressive and rapidly fatal |
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Describe Mycosis fungoides Sezary syndrome (6) |
- T-cell lymphoma of skin - Associated with patches, plaques, tumors - Nuclei look like brains (cerebriform) - Pautrier microabscesses - Indolent - CD4+, CD8-, |
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What is Sezary syndrome? |
erythroderma + blood involvement |
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Describe Anaplastic Large Cell Lymphoma. (4) |
- T-cell lymphoma - CD30+, ALK - Extra-nodal disease - High stage but good prognosis |
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What translocation and gene are responsible for Anaplastic Large Cell Lymphoma? |
t(2;5) NPM-ALK |
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Describe Lymphoblastic lymphoma. (6) |
- Very aggressive precursor T-cell lymphoma - Usually children - Mediastinal involvement - Lymphoblasts - CD3 (or CD19 if B-cell), TdT - Related to ALL |
