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14 Cards in this Set
- Front
- Back
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Source of Infection of N. Mengitidis
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Nasopharynx colonization
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Types of infection of N. Menigitidis
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Meningitis and sepsis.
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Risk factors for developing meningitis by meningococcus?
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Genetic defects in Ig or complement C5-9
Inability to form MAC complex to kill cells Asplenia/dysfunctional spleen sickle cell disease |
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Treatment for N. Mengitidis
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1. Broad Spectrum antibiotics first
2. After identifying, Penicillin and cephalosporins 3. Prophylaxis with Rifampicin, fluoroquinolones, cephalosporins. |
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Prevention of N. Menigitidis
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MCV4 vaccine with diptheria toxin
enhanced and durable T Cell antibody response No vaccine against Serotype B b/c sialic acid also present in humans. |
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Pathogenesis of N. mengitidis
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1. Antiphagocytic capsule: Serogroups B and C in USA
2. Pili>binds non ciliated nasopharyngeal epithelial cells 2. Cell wall components LPS/endotoxin and peptidoglycan 4. Damage cells>entry into blood stream 5. Immune evasion by antigenic variation & phase variation Antigenic variation: Pilin, Opa, LOS (LPS) & capsule 6. Iron acquisition: binds transferrin and lactoferrin 8. No siderophores 9. DNA relase and uptake = antigenic variation 10. NONMOTILE/NO FLAGELLA |
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Complications of N. Neisseria
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Pelvic inflammatory disease
Fallopian Tube Scarring Infertility Ectopic pregnancy Ocular infection to newborn ANTIBIOTIC RESISTANCE AND NO VACCINE! |
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Virulance Determinants H. Influenzae
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(1) Serotype B
(2) Capusule made of PolyriBosyl riBitol phosphate |
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What age group is affected by encapsulated type B H. Influenzae
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iii) Affects kids between several months old and 5 years of age
(1) Babies have maternal abs and older kids develop immunity |
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Risk factors for infection by Type B. H. Influenzea
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(1) Asplenia
(2) Mutant complement or immunoglobulins |
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transmission of Encapsulated Type B H. Influenzea
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(1) Respiratory droplets
(2) Nasopharynx>blood>CNS>invasive disease>sepsis and meningitis |
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Extension of disease by Type B encapsulated H. Influenzae?? What three diseases?
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(1) Cellulitis-orbital and buckle
(2) Epiglottitis- (3) Mastoiditis |
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What distinguishes unencapsulated H. Influenzae from encapsulated?
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i) Rarely sepsis or mengigitis
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What syndromes are caused by H. Influenzae unencapsulated
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(1) Asymptomatic nasopharyngeal colonization
(2) Normal vaginal flora (3) Sinusitis (4) Conjunctivitis (day cares) (5) Otitis media (6) Bronchitis (7) Pneumonia Premature birth, chorioamnioitis, postpartum sepsis, neonatal infections: sepsis, menigitis, pneumonia |
