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90 Cards in this Set
- Front
- Back
What are the chances that coin lesion on CXR is malignant?
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50% at 50. Under 50 chances decrease, over 50 chances increase
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What do benign lesions looks like vs malignant?
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Benign has smooth surfaces, malig has irregular or spiculated surfaces
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What are other benign lesions?
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Bulls' eyes, hamartomas which have popcorn appearance on CXR
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Which area of US are coin lesions common?
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SW US where coccidiomycosis is common and mid atlantic and OH valley where Histo occurs
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Most common mets to the lung are from?
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Colorectal, breast, renal
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If a lung lesion looks malignant what do you do?
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Get a CT to characterize lesions and to look for enlarged lymph nodes in mediastinum, then do CT guided needle biopsy
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What do you do if needle biopsy shows malig or indeterminate?
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Resection
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What do you do for lesion with cough and hemoptysis and mediastinal enlarged lymph node?
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Bronchoscopy for tissue diag and to determine location of lesion. and mediastinoscopy to det state of mediastinal LNs
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What doubling time favors benign status vs malignant status?
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If doubling time is <5wks or >465 days then it favors benign. If doubling time is 5 weeks to 280 days, favors malig
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What type of LC usually presents late and not amenable to resection?
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Small Cell Carcinoma
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Cure rate for stage I tumors w resection?
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70%
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Stage II LC 5 year survival?
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40-50%
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Surgical options for metastatic lesion involving mainstem bronchus
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Pneumonectomy (easier) or sleeve lobectomy (safer). Sleeves are not feasible if main pulmonary artery is invaded
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Perioperative death rate from pneumonectomy?
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5-10% especially in those over 70 and those with cardiac or obstructive airway dz
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At what stages can tumors be resected?
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Stages I and II
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At what stages are chemo and radiation the only treatments?
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Stages III and IV
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Ipsilateral hilar lymph nodes are what stage?
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Stage II
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Mediastinal LNs are what stage?
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Stage III
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Can a tumor undergo chemo and be downstaged and resected?
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Yes
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Imaging modality good for detecting lung cancer mets?
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PET scan
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Symptoms of Pancoast tumor?
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Horner's syndrome, pain in ulnar area of elbow and wrist
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How to verify superior sulcus tumor?
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CT, bronchoscopy, mediastinascopy, needle biopsy
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what are 5 year survivals for stage II, IIIa, and IIIb LC?
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44%, 22%, and <10%
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Tx of Pancoast tumor?
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1. Irradiation over the course of 6 wks then surgical resection of chest wall and lung
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In a young healthy patient with hemoptysis and atelectasis, what would be suspect?
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Bronchial adenoma that's obstructing a bronchus
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2 types of bronchial adenomas?
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1. Carcinoids (malignant potential if originated in small bowel)
2. Adenocystic carcinomas (invade locally) |
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How to diagnose bronchial adenoma?
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Bronchoscopy with biopsy. careful cause they bleed.
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How to treat bronchial adenomas?
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Lobectomy. Usually curative.
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Carcinoid syndrome sxs?
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Flushing, diarrhea, wheezing from bronchospasm, Facial telangectasia, tricuspid regurg and pulmonary stenosis because serotonin increases collagen production in valves
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Differential diag for effusion?
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Cancer: bronchiogenic carcinoma, mesothelioma
Benign: CHF, viral/bact pna, empyema, TB |
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How to diag an effusion?
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Thoracentesis and pleural biopsy. you can culture the fluid and examine histology of biopsy for malignancy
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Prognosis for mesothelioma?
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Terrible. Most dead within a year. Not responsive to chemo/rad.
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Only surgical tx for mesothelioma?
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Extrapleural pneumonectomy. Takes out lung, both visceral and parietal pleura, pericardium, and diaphragm at times
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Etiology of spontaneous pneumothorax?
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rupture of apical blebs, pleural cavity pressure becomes same as atm, causes lung collapse and trachea deviated to side of collapse
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Etiology of tension pneumo?
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penetrating trauma to the lungs, pleural tear that allows air only to go into pleural space, trachea deviates to contralateral side
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Tx of a pneumo?
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Chest tube
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What do you do if patient unresponsive to chest tube?
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Must investigate persistent air leaks from lung parenchyma with thoracoscope and surgical intervention
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How to treat persistent or recurrent pneumo?
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1. thoracoscopic excision of blebs and pleurodesis (pleural abrasion to adhere visceral and parietal pleura)
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What do you suspect with chest pain, cough, recurrent fever, and pleural effusion after a pneumonia treatment?
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Empyema
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Most common causes of empyema?
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S.pneumo
Staph and gram neg in hospitals Anaerobes if aspiration suspected or alcoholism or recent operation |
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How often are empyema culture neg?
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35% b/c of previous abx tx
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How to treat empyema?
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1. empiric abx
2. Chest tube for drainage |
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What happens if you don't treat an empyema?
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1. exudative phase
2. fibropurulent stage (loculation of fluid pockets) 3. organizing stage (scarring and inflammatory tissue) |
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How do you fix an untreated empyema?
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1. thoracotomy and decortication
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How to manage unstable angina?
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1. Admit and bed rest
2. Oxygen 3. Beta blockers, Nitro, ASA, heparin, morphine is questionable 4. Cardiac enzymes 5. Cath or thrombolysis if MI+ |
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3 major coronary arteries?
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1. RCA
2. LAD 3. Cx (LAD and Cx from left main) |
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what's an abnormal EF?
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<40-50%
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How to treat left main dz?
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Coronary artery bypass
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Alternative to bypass?
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PTCA with stents, danger of reobstruction
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Sources of bypass grafts?
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Internal mammary A has best patency, reversed greater saphenous V also used
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What solutions used to help performance of bypass?
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Cardioplegia solution, blood cardioplegia solution, hypothermia
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Operative mortality for bypass surgeries?
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3%, but less for low riskers
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Etiology of MVR?
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Myxomatous degeneration of MV. Thought to be due to ischemia of mitral value apparatus
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How is MVP different from MVR?
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Prolapse is eccentric closure and doesn't have to regurg. Common in young women, but in men it can be a sign of severe mitral valve dz.
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Etiologies of Mitral stenosis?
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Rh fever, Scarlet fever
you get inflammation of connective tissues, leaflets progressively fuse, LA pressure goes up, R heart enlargement, pulmonary htn |
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Treatment of mitral valve dz?
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Can try to repair regurg by excision of redundant portion of leaflefts and reinforcing mitral annulus with annuloplasty ring, but can replace if not successful
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3 etiologies of aortic stenosis
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1. Congenital (bicuspid valve)
2. arteriosclerotic 3. deteriorative |
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Aortic valve area less that what is severe stenosis?
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0.8cm sq
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Workup for aortic stenosis?
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1. Cardiac cath to det aortic valve size, pressure grad, vent function, check for CAD.
2. Carotid doppler to rule out internal carotid obstruction |
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When do pts with aortic stenosis usually present?
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late in life. extreme risk for sudden death.
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Pros and cons of mech vs tissue valves
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Mech valves need anticoagulation b/c they are thrombogenic
Tissue valves nonthrombogenic but deteriorate. require replacement at 7 years. |
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What can give you dilated cardiomyopathy if you've got normal coronary arteries?
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post-respiratory illness. etiology unclear.
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prognosis for dilated cardiomyopathy?
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1/3 get better, 1/3 stay the same, 1/3 get worse
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Tx for dilated cardiomyopathy?
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steroids, diuretics, immunosuppressives, beta blockers, transplant
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Prognosis with transplant?
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Immediate survival >90%
Survival @ 1 year is 85-90% Survival @ 2 years is 75% |
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Immunosuppressives for transplants?
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Cyclosporine, tacrolimus
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Most deaths from transplants happen from what?
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infection from immunosuppressive drugs and accelerated coronary atherosclerosis as a form of chronic rejection
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What do we suspect with regurgitated undigested food and dysphagia?
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Zenker's diverticulum or pharyngeal diverticulum
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Etiology of pharyngeal diverticulum?
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Abnormal uncoordinated constriction of cricopharyngeal muscle during swallow results in outpouching between lower pharyngeal constrictor and cricopharyngeal muscle
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Where else can a pulsion diverticulum occur?
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distal esophagogastric junction: epiphrenic diverticulum. food can regurgitate and can be aspirated
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tx for pharyngeal divert?
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1. Excision if diverticulum is large
2. trasect cricopharyngeal muscle to relax esophageal entrance and prevent uncontrolled contraction |
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Tx for epiphrenic divert?
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Esophageal myotomy at esophageal gastric junc
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Sxs and etiology of achalasia?
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dysphagia, WL due to poor peristalsis of body of esophagus and failure of LES to relax. Loss of smooth muscle ganglionic cells of Auerbach plexus
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How to diagnose achalasia?
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barium swallow
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Associated conditions with achalasia?
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Emotional stress, physical trauma, WL, Chagas
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Tx for achalasia?
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Heller myotomy or pneumatic dilation. Maybe Ca blockers
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Types of cancers in different areas of esophagus?
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top 2/3 is squamous cell carcinoma, bottom 1/3 adenocarcinoma
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Esophageal cancer assoc w/ what?
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Alcohol, tobacco, Barrett's (40x w/ severe dysplasia)
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How do you stage esophageal cancer?
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Endoscopic US for wall penetration and LN spread. CT abd and chest for celiac node involvement. Mediastinal or celiac node mets automatically stage III and incurable
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Complication with middle third esophageal cancers?
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invasion of trachebronchial tree
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Tx for esophageal ca?
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Depends on stage and location.
Stage I (just to submucosa) can be resected but not in upper third of esophagus. Stage II and beyond is chemoradiation. But you can downstage then try to resect. |
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Two types of esophagectomies and types of incisions?
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Formal (upper abd and thorax incision)
Transhiatal (cervical and upper abd incision) We want the anastamosis at the cervical area for easy access in case of complications |
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What do we do after an esophagectomy anastamosis?
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Pyloroplasty to prevent gastric outlet obstruction
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Why would a person with esophageal ca have constant cough?
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Tracheoesophageal fistula from tumor invasion
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Palliative methods for esophageal ca?
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Esophageal stent, gastrostomy tube, radiation, pall resection, supportive care
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What type of tumor assoc w/ weakness and double vision?
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Thymoma assoc w Myasthenia gravis
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Lymphoma tx?
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Rad + chemo
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Common tumors of anterosuperior mediastinum?
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Thymomas, Lymphomas, Germ cell tumors
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Common tumors of middle mediastinum?
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Cysts (bronchiogenic/pericardial), lymphomas, Mesenchymal
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Common tumors of posterior mediastinum?
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Neurogenic neurilemomas from nerves and nerve sheaths
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