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90 Cards in this Set

  • Front
  • Back
What are the chances that coin lesion on CXR is malignant?
50% at 50. Under 50 chances decrease, over 50 chances increase
What do benign lesions looks like vs malignant?
Benign has smooth surfaces, malig has irregular or spiculated surfaces
What are other benign lesions?
Bulls' eyes, hamartomas which have popcorn appearance on CXR
Which area of US are coin lesions common?
SW US where coccidiomycosis is common and mid atlantic and OH valley where Histo occurs
Most common mets to the lung are from?
Colorectal, breast, renal
If a lung lesion looks malignant what do you do?
Get a CT to characterize lesions and to look for enlarged lymph nodes in mediastinum, then do CT guided needle biopsy
What do you do if needle biopsy shows malig or indeterminate?
Resection
What do you do for lesion with cough and hemoptysis and mediastinal enlarged lymph node?
Bronchoscopy for tissue diag and to determine location of lesion. and mediastinoscopy to det state of mediastinal LNs
What doubling time favors benign status vs malignant status?
If doubling time is <5wks or >465 days then it favors benign. If doubling time is 5 weeks to 280 days, favors malig
What type of LC usually presents late and not amenable to resection?
Small Cell Carcinoma
Cure rate for stage I tumors w resection?
70%
Stage II LC 5 year survival?
40-50%
Surgical options for metastatic lesion involving mainstem bronchus
Pneumonectomy (easier) or sleeve lobectomy (safer). Sleeves are not feasible if main pulmonary artery is invaded
Perioperative death rate from pneumonectomy?
5-10% especially in those over 70 and those with cardiac or obstructive airway dz
At what stages can tumors be resected?
Stages I and II
At what stages are chemo and radiation the only treatments?
Stages III and IV
Ipsilateral hilar lymph nodes are what stage?
Stage II
Mediastinal LNs are what stage?
Stage III
Can a tumor undergo chemo and be downstaged and resected?
Yes
Imaging modality good for detecting lung cancer mets?
PET scan
Symptoms of Pancoast tumor?
Horner's syndrome, pain in ulnar area of elbow and wrist
How to verify superior sulcus tumor?
CT, bronchoscopy, mediastinascopy, needle biopsy
what are 5 year survivals for stage II, IIIa, and IIIb LC?
44%, 22%, and <10%
Tx of Pancoast tumor?
1. Irradiation over the course of 6 wks then surgical resection of chest wall and lung
In a young healthy patient with hemoptysis and atelectasis, what would be suspect?
Bronchial adenoma that's obstructing a bronchus
2 types of bronchial adenomas?
1. Carcinoids (malignant potential if originated in small bowel)
2. Adenocystic carcinomas (invade locally)
How to diagnose bronchial adenoma?
Bronchoscopy with biopsy. careful cause they bleed.
How to treat bronchial adenomas?
Lobectomy. Usually curative.
Carcinoid syndrome sxs?
Flushing, diarrhea, wheezing from bronchospasm, Facial telangectasia, tricuspid regurg and pulmonary stenosis because serotonin increases collagen production in valves
Differential diag for effusion?
Cancer: bronchiogenic carcinoma, mesothelioma
Benign: CHF, viral/bact pna, empyema, TB
How to diag an effusion?
Thoracentesis and pleural biopsy. you can culture the fluid and examine histology of biopsy for malignancy
Prognosis for mesothelioma?
Terrible. Most dead within a year. Not responsive to chemo/rad.
Only surgical tx for mesothelioma?
Extrapleural pneumonectomy. Takes out lung, both visceral and parietal pleura, pericardium, and diaphragm at times
Etiology of spontaneous pneumothorax?
rupture of apical blebs, pleural cavity pressure becomes same as atm, causes lung collapse and trachea deviated to side of collapse
Etiology of tension pneumo?
penetrating trauma to the lungs, pleural tear that allows air only to go into pleural space, trachea deviates to contralateral side
Tx of a pneumo?
Chest tube
What do you do if patient unresponsive to chest tube?
Must investigate persistent air leaks from lung parenchyma with thoracoscope and surgical intervention
How to treat persistent or recurrent pneumo?
1. thoracoscopic excision of blebs and pleurodesis (pleural abrasion to adhere visceral and parietal pleura)
What do you suspect with chest pain, cough, recurrent fever, and pleural effusion after a pneumonia treatment?
Empyema
Most common causes of empyema?
S.pneumo
Staph and gram neg in hospitals
Anaerobes if aspiration suspected or alcoholism or recent operation
How often are empyema culture neg?
35% b/c of previous abx tx
How to treat empyema?
1. empiric abx
2. Chest tube for drainage
What happens if you don't treat an empyema?
1. exudative phase
2. fibropurulent stage (loculation of fluid pockets)
3. organizing stage (scarring and inflammatory tissue)
How do you fix an untreated empyema?
1. thoracotomy and decortication
How to manage unstable angina?
1. Admit and bed rest
2. Oxygen
3. Beta blockers, Nitro, ASA, heparin, morphine is questionable
4. Cardiac enzymes
5. Cath or thrombolysis if MI+
3 major coronary arteries?
1. RCA
2. LAD
3. Cx

(LAD and Cx from left main)
what's an abnormal EF?
<40-50%
How to treat left main dz?
Coronary artery bypass
Alternative to bypass?
PTCA with stents, danger of reobstruction
Sources of bypass grafts?
Internal mammary A has best patency, reversed greater saphenous V also used
What solutions used to help performance of bypass?
Cardioplegia solution, blood cardioplegia solution, hypothermia
Operative mortality for bypass surgeries?
3%, but less for low riskers
Etiology of MVR?
Myxomatous degeneration of MV. Thought to be due to ischemia of mitral value apparatus
How is MVP different from MVR?
Prolapse is eccentric closure and doesn't have to regurg. Common in young women, but in men it can be a sign of severe mitral valve dz.
Etiologies of Mitral stenosis?
Rh fever, Scarlet fever
you get inflammation of connective tissues, leaflets progressively fuse, LA pressure goes up, R heart enlargement, pulmonary htn
Treatment of mitral valve dz?
Can try to repair regurg by excision of redundant portion of leaflefts and reinforcing mitral annulus with annuloplasty ring, but can replace if not successful
3 etiologies of aortic stenosis
1. Congenital (bicuspid valve)
2. arteriosclerotic
3. deteriorative
Aortic valve area less that what is severe stenosis?
0.8cm sq
Workup for aortic stenosis?
1. Cardiac cath to det aortic valve size, pressure grad, vent function, check for CAD.
2. Carotid doppler to rule out internal carotid obstruction
When do pts with aortic stenosis usually present?
late in life. extreme risk for sudden death.
Pros and cons of mech vs tissue valves
Mech valves need anticoagulation b/c they are thrombogenic
Tissue valves nonthrombogenic but deteriorate. require replacement at 7 years.
What can give you dilated cardiomyopathy if you've got normal coronary arteries?
post-respiratory illness. etiology unclear.
prognosis for dilated cardiomyopathy?
1/3 get better, 1/3 stay the same, 1/3 get worse
Tx for dilated cardiomyopathy?
steroids, diuretics, immunosuppressives, beta blockers, transplant
Prognosis with transplant?
Immediate survival >90%
Survival @ 1 year is 85-90%
Survival @ 2 years is 75%
Immunosuppressives for transplants?
Cyclosporine, tacrolimus
Most deaths from transplants happen from what?
infection from immunosuppressive drugs and accelerated coronary atherosclerosis as a form of chronic rejection
What do we suspect with regurgitated undigested food and dysphagia?
Zenker's diverticulum or pharyngeal diverticulum
Etiology of pharyngeal diverticulum?
Abnormal uncoordinated constriction of cricopharyngeal muscle during swallow results in outpouching between lower pharyngeal constrictor and cricopharyngeal muscle
Where else can a pulsion diverticulum occur?
distal esophagogastric junction: epiphrenic diverticulum. food can regurgitate and can be aspirated
tx for pharyngeal divert?
1. Excision if diverticulum is large
2. trasect cricopharyngeal muscle to relax esophageal entrance and prevent uncontrolled contraction
Tx for epiphrenic divert?
Esophageal myotomy at esophageal gastric junc
Sxs and etiology of achalasia?
dysphagia, WL due to poor peristalsis of body of esophagus and failure of LES to relax. Loss of smooth muscle ganglionic cells of Auerbach plexus
How to diagnose achalasia?
barium swallow
Associated conditions with achalasia?
Emotional stress, physical trauma, WL, Chagas
Tx for achalasia?
Heller myotomy or pneumatic dilation. Maybe Ca blockers
Types of cancers in different areas of esophagus?
top 2/3 is squamous cell carcinoma, bottom 1/3 adenocarcinoma
Esophageal cancer assoc w/ what?
Alcohol, tobacco, Barrett's (40x w/ severe dysplasia)
How do you stage esophageal cancer?
Endoscopic US for wall penetration and LN spread. CT abd and chest for celiac node involvement. Mediastinal or celiac node mets automatically stage III and incurable
Complication with middle third esophageal cancers?
invasion of trachebronchial tree
Tx for esophageal ca?
Depends on stage and location.
Stage I (just to submucosa) can be resected but not in upper third of esophagus. Stage II and beyond is chemoradiation. But you can downstage then try to resect.
Two types of esophagectomies and types of incisions?
Formal (upper abd and thorax incision)
Transhiatal (cervical and upper abd incision)
We want the anastamosis at the cervical area for easy access in case of complications
What do we do after an esophagectomy anastamosis?
Pyloroplasty to prevent gastric outlet obstruction
Why would a person with esophageal ca have constant cough?
Tracheoesophageal fistula from tumor invasion
Palliative methods for esophageal ca?
Esophageal stent, gastrostomy tube, radiation, pall resection, supportive care
What type of tumor assoc w/ weakness and double vision?
Thymoma assoc w Myasthenia gravis
Lymphoma tx?
Rad + chemo
Common tumors of anterosuperior mediastinum?
Thymomas, Lymphomas, Germ cell tumors
Common tumors of middle mediastinum?
Cysts (bronchiogenic/pericardial), lymphomas, Mesenchymal
Common tumors of posterior mediastinum?
Neurogenic neurilemomas from nerves and nerve sheaths