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21 Cards in this Set

  • Front
  • Back
What factor causes arteriole vasodilation after injury?
endothelin
What does an activated platelet do?
it changes shape and releases secretory granules
What three factors prevent platelets from binding to uninjuried tissue?
NO, ADPase, PGI2
What two factors prevent coagulation?
thrombomodulin, heparin like ptns
Which factors does ptn C cleave?
5 and 8
What produces von Willebrand factor?
endothelial cells
What produces tissue factor?
endothelial cells
What dx results from a defect in GpIb?
Bernard-Soulier syndrome
What is Bernard-soulier syndrome?
a defectin GpIb
What is von Willebrand Dx?
defeciency of vWF
What receptor binds fibrinogen?
GpIIb-IIIa
What happens without GpIIb-IIIa?
glanzmann thrombastenia
What opposes PGI2?
TxA2
What does the phospholipid complex do?
help with binding of components of intrinsic cascade
What is the Haneman factor?
XII, the start of intrisic
What happens to laminar flow with stasis or turbulance?
brings platelets into contact with endothelium
What is the function of a clot?
to prevent excessive loss of blood from ruptured vessels
What causes vasoconstriction initially?
endothelin
When do platelets become active?
when exposed to endothelial collagen
What do platelets release when activated?
ADP, TxA2, serotonin
What do ADP, TxA2, and serotonin do?
recruit other platelets