Njds Pathology - Cellular Pathology I: Intro

Front 1

Homeostasis

Back 1

Within a narrow physiological range that cells can maintain a fairly constant microenvironment, or internal steady state.

Front 2

Adaptation

Back 2

Cells adjust their internal micro-environment in response to external stressful stimuli to achieve a NEW STEADY STATE

1. Cell remains HEALTHY and VIABLE
2. Potentially REVERSIBLE

Front 3

4 kinds of adapation

Back 3

1. Hypertrophy
2. Hyperplasia
3. Atrophy
4. Metaplasia

Front 4

4 response types to cell injury

Back 4

1. Acute reversible (sublethal) cell injury
2. Irreversible (lethal) cell injury
3. Intracellular accumulation
4. Pathological calcification

Front 5

Acute reversible injury

Back 5

a.k.a - sublethal injury

1. Damage not enough to kill cell
2. Reversible to original structural/functional state upon stimuli removal

Front 6

7 different types of stressful/injurious cell stimuli

Back 6

1. inadequete oxygen
2. physical agents
3. chemicals
4. microbiologic agents
5. immunological
6. genetic
7. nutritional

Front 7

Factors of stress that determine how a cell will respond

Back 7

1. Type of stress
2. Duration of stress
3. Intensity of stress

Front 8

Factors of a cell that determine how it will respond to stress

Back 8

1. Type of cell
2. Current physiological status
3. Inherent ability to respond

Ex: cerebral neurons are highly sensitive that die rapidly when subject to changes outside their physiological range while fibroblasts are very hardy cells that can survive severe changes in their environment without apparent effect.