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8 Cards in this Set

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Within a narrow physiological range that cells can maintain a fairly constant microenvironment, or internal steady state.
Cells adjust their internal micro-environment in response to external stressful stimuli to achieve a NEW STEADY STATE

1. Cell remains HEALTHY and VIABLE
2. Potentially REVERSIBLE
4 kinds of adapation
1. Hypertrophy
2. Hyperplasia
3. Atrophy
4. Metaplasia
4 response types to cell injury
1. Acute reversible (sublethal) cell injury
2. Irreversible (lethal) cell injury
3. Intracellular accumulation
4. Pathological calcification
Acute reversible injury
a.k.a - sublethal injury

1. Damage not enough to kill cell
2. Reversible to original structural/functional state upon stimuli removal
7 different types of stressful/injurious cell stimuli
1. inadequete oxygen
2. physical agents
3. chemicals
4. microbiologic agents
5. immunological
6. genetic
7. nutritional
Factors of stress that determine how a cell will respond
1. Type of stress
2. Duration of stress
3. Intensity of stress
Factors of a cell that determine how it will respond to stress
1. Type of cell
2. Current physiological status
3. Inherent ability to respond

Ex: cerebral neurons are highly sensitive that die rapidly when subject to changes outside their physiological range while fibroblasts are very hardy cells that can survive severe changes in their environment without apparent effect.