Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
What are the four major NFGNB?
|
(1) Pseudomonas aeruginosa
(2) Stenotrophomonas maltophila (3) Acinetobacter (4) Burkholderia cepecia |
|
|
NFGNB's special niche:
(1) Where can they grow? (2) Mech of resistance (3) Mutation |
(1) diverse areas of hospital
(2) imperm outer memb, efflux pumps (3) rapidly mutate or acquire genetic material |
|
|
When NFGNB is isolated, what is the first and most important thing you should do?
|
Identify whether an infection is present (vs. colonization)
|
|
|
Pseudomonas aeruginosa:
(1) common cause of mortality in which pts? (2) often in assoc w/ what environ? (3) pathogenesis/virulence (4) treatment |
(1) hospitalized, chronic lung disease
(2) water - hottub folliculitis! (3) LPS = shock, toxins = tissue damage, slime = difficult eradication (4) inherently resistant to B-lactams, etc. -- use macrolides w/ aminoglycoside |
|
|
Pseudomonas aeruginosa:
Major infections (6) |
(1) ventilater pneumonia
(2) catheter bacteremia (3) UTI (4) post-op wound infection (5) burn/neutropenic bacteremia (6) CF lung infection *** bacteremic ecthyma gangrenosum - armpit PA, necrotic lesions |
|
|
Stenotrophomonas maltophila:
(1) classic pt (2) pathogensis (3) treatment |
(1) carbapenems, malignancy, ICU, catheters
(2) not many virulence factors (3) trimethoprim-sulfa (resistant to B-lactam) |
|
|
Stentrophomonas maltophila:
Major infections (4) |
(1) catheter bacteremia
(2) ventilator pneumonia (3) skin/soft-tissue infection (4) nosocomial meningitis |
|
|
Acinetobacter (baumanni):
(1) where are outbreaks? (2) classic pt (3) pathogenesis (4) treatment |
(1) nosocomial (soldier hospitals in Iraq)
(2) ICU, broad-spec antibiotics, catheter (3) not many virulence factors (4) sulbactam |
|
|
Acinetobacter (baumanni):
Major infections (4) |
(1) ventilator pneumonia
(2) catheter bacteremia (3) skin/soft-tissue infection (4) intra-abd infection |
|
|
Burkholderia cepacia complex (BCC):
(1) usu pts (2) major infections (3) pathogenesis (4) treatment |
(1) CF, chronic granulomatous disease (CGD)
(2) CF = lung infection, CGD = necrotizing pneumonia/bacteremia (3) LPS = inflamm, biofilm = persistance, host factors (4) big prb b/c inherently resistant |
