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28 Cards in this Set
- Front
- Back
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What is hte main excitatory nt of the brain?
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Glutamate
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What nt is deficient in Parkinson's disease?
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DA
-progressive degeneration of the nigrostrial pathway |
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Trx for Parkinson's?
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Monamine oxidase B inhibitor
ex. Deprenyl |
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What nt are targeted by tricyclic antidepressants?
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NE and 5HT up-take
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What nt are associated with Huntington's (Chorea)?
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GABA, ACh decrease
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What partsof the brain are lost in Huntingtons?
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putamen and caudate nucleus of the cerebral cortex
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What nt is Schizophrenia assocaited with?
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Increased DA in the limbic system
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Can DA cross the BBB?
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No
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What can be given the Parkinsons pt to increase their DA levels?
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L-DOPA
DA precursor that can cross the BBB |
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What is the committing and rate limiting step of catecholamine synetheis?
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Tyrosine hydroxylase
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Monamine oxidase a has a preference for what nt?
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NE and 5HT
inhibited by clorgyline |
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Monamine oxidase b has a preference for what nt?
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DA and N-methyhistamine
Inhibited by Deprenyl |
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What 2 enzymes are required for DA metabolism?
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Monamine oxidase and Catecholamine-o-methy transferase
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What is the endproduct of DA metabolism?
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homovanillate
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What is NE broken down to in the periphery?
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vanillylmandalate
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What is urinary vanillylmandalate diagnostic for?
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detection of a pheochromocytoma (adrenal medulla catecholamine secreting tumor)
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What is NE broken down to in the CNS?
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3-methoxy-4hydroxyphenylglycoaldehyde
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What is 5HT broken down to?
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5-Hydroxyindole acetate
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How is 5HT signaling terminated?
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Na dependent uptake
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What does GABA R-a have allosteric binding sites for?
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diazapam and barbituates
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How is GABA transmission stopped?
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Its taken up by glial cells, where it is broken down to glutamine.
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How is glycine transmission stopped?
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Na dependent uptake to the pre-synaptic cell.
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What needs to bing NMDA R to activate them?
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Glycine and glutamine
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In the CNS, what is histamine metabolized to?
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N-methyimidazole acetate
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In the periphery, what is histamine metabolized to?
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Imidazole acetate
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What are the 3 opiod peptides?
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POMC, enkephalins, dynorphins
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How are the opiod peptides activated and inactivated?
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Proteolytic clevage
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What can you not take with nitroglycerine?
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Viagra--NO metabolism
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