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14 Cards in this Set
- Front
- Back
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5 Characteristics of chemical nt?
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synthesis
storage release binding inactivation/termination |
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Effect of 5HT on pre-synaptic nerve?
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Increases excitation
-Binds and activates adenylate cyclase, increases cAMP, activates kinase, which P's K channels--causes them to close and cell depolarizes for longer--more Ca in means more nt out |
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What nt is found at NMJ?
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Ach
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What is the major inhibitory nt in the brain?
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GABA
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What is the major inhibitory nt in the brain stem and SC?
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glycine
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What is hte mechanism of both GABA and glycine?
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Open Cl channel allowing for hyperpolarization of the cell
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What occurs in myasthenia gravis?
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AB to nAChR, which causes internalization and degredation
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What are the 2 strucutral features of importance on the nAChR?
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Nt binding site and M2 alpha helix
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What is special about the M2 alpha helix that allows ions to "shoot through"?
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Lots of neg charged aa that with conformational changes, pass the ion down the chain into the cell
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What is the mechanism of signal transduction of the mAChR?
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G protein mediated signal transduction
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What enzyme makes Ach from Acety-CoA and Choline?
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Choline Acetyltransferase
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How are vessicles loaded with nt at the synaptic cleft?
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H+ ATPase pump is used to lower vessicle pH then nt are "anti-ported" into the vessicles in place of the protons
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Where are the 2 places you find AchE in the synaptic cleft?
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Membrane bound on the post-synaptic cell and bound to basal lamina in the cleft (fibers that run from pre to post synpatic cell)
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What 2 chemicals are AChE inhibitors?
Used for insecticides and chemical warfare.. |
diidoflurophosphate (DFP)--suicide inhibitor
BB'dichlorodiethylsulfide --alkylating agent in mustard gas |
