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14 Cards in this Set

  • Front
  • Back
Apamin
Honey bee
-blocks Ca-dependent K channels
Botulinum toxin
Clostridium botulinum
-blocks Ach release
-heavy chain allows entry into presynaptic terminal.
-light chain is toxin-part that cleaves SNAP-25.
-reversible dennervation
-if ingested: dilated fixed pupils
Latrotoxin
Black widow
-enhances Ach release
Cobrotoxin
Cobra
-blocks Ach (nicotinic) receptors
alpha-bungarotoxin
Krait (snake) venom
-blocks Ach (nicotinic) receptors
Capsaisin
Cayenne pepper
-decreases substance P
Domoic acid
Blue mussel (Canada)
-Glutamate/kainate receptor agonist
-"Amnestic shellfish poisoning"
-Seizures
Methylazoxymethanol (MMA) toxin
Cycad plant
-damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. Seen in "ALS-Parkinsonism-Dementia Complex of Guam"
Ciguatoxin
Dinoflagellate
-opens Na (and Ca) channels
-Large fish in Florida/Hawaii
Brevotoxin
Red Tide dinoflagellate
-opens Na channels
-shellfish in Gulf of Mexico and Caribbean
Saxitoxin
Dinoflagellate
-blocks VG-Na channels (reversibly)
-"Paralytic shellfish poisoning"
-bivalve mollusks in NE/NW USA
Tetrodotoxin (TTX)
Pufferfish (Japan)
-blocks VG-Na channels (reversibly)
Histamine toxin
Scombroid
-fish rich in dark meat
Okadaic acid
Shellfish
-inhibition of phosphorylase phosphatase
-"Diarrheal shellfish poisoning"