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14 Cards in this Set
- Front
- Back
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Apamin
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Honey bee
-blocks Ca-dependent K channels |
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Botulinum toxin
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Clostridium botulinum
-blocks Ach release -heavy chain allows entry into presynaptic terminal. -light chain is toxin-part that cleaves SNAP-25. -reversible dennervation -if ingested: dilated fixed pupils |
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Latrotoxin
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Black widow
-enhances Ach release |
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Cobrotoxin
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Cobra
-blocks Ach (nicotinic) receptors |
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alpha-bungarotoxin
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Krait (snake) venom
-blocks Ach (nicotinic) receptors |
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Capsaisin
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Cayenne pepper
-decreases substance P |
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Domoic acid
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Blue mussel (Canada)
-Glutamate/kainate receptor agonist -"Amnestic shellfish poisoning" -Seizures |
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Methylazoxymethanol (MMA) toxin
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Cycad plant
-damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. Seen in "ALS-Parkinsonism-Dementia Complex of Guam" |
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Ciguatoxin
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Dinoflagellate
-opens Na (and Ca) channels -Large fish in Florida/Hawaii |
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Brevotoxin
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Red Tide dinoflagellate
-opens Na channels -shellfish in Gulf of Mexico and Caribbean |
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Saxitoxin
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Dinoflagellate
-blocks VG-Na channels (reversibly) -"Paralytic shellfish poisoning" -bivalve mollusks in NE/NW USA |
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Tetrodotoxin (TTX)
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Pufferfish (Japan)
-blocks VG-Na channels (reversibly) |
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Histamine toxin
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Scombroid
-fish rich in dark meat |
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Okadaic acid
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Shellfish
-inhibition of phosphorylase phosphatase -"Diarrheal shellfish poisoning" |
