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12 Cards in this Set
- Front
- Back
Which nerve rootlets are invaded by a Pancoast tumor?
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Cervical - VIII
Thoracic - I |
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What is the resulting syndrome of the interruption of sympathetic nerve fibers from the superior cervical ganglion
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Horner's Syndrome
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Why is there weakness associated with this disease?
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There is an autoimmune response that attacks the P/Q Ca channels in the synapse. This does not allow Ach to be efficiently released.
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Why does excercise reduce the weakness?
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With prior activity (exercise), Ca2+ builds up in the pre-synaptic neuron and permits greater ACh release, somewhat rescuing the muscle activity.
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How long to SCLC patients live if untreated?
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6-17 weeks
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What drug is the main drug used to help the muscle weakness?
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Neostigmine
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What three things does LES present with?
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1. Proximal muscle weakness
2. Lack of tendon reflexes 3. Dysfunction of autonomics |
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How does LES affect the compound AP produced after continuous contraction?
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Reduced compound muscle action potential that shows potentiation following contraction.
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In LES are the minature endplates normal? How about the AchRs?
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Miniature EPPs (single quanta) are normal-- as are muscle ACh receptors
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How do the antibodies against the Ca channels affect the channels?
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Reduced Ca2+ influx is not due to blockade of channel directly-- hypothesis is that the autoantibody cross-links to the channel antigen and increases its rate of channel internalization.
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What type of tissue do SCLC develop from?
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SCLCs develop from neuroectoderm -- will be related to neural tissue.
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What happens to the normal quantal release in a LES patient?
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It is reduced due to the reduction of Ca influx. This means less vesicles fuse to release Ach.
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