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23 Cards in this Set
- Front
- Back
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mixed alpha & beta agonists
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Epinephrine
Ephedrine Pseudoephedrine Norepinephrine (but beta-1 >>beta-2) |
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alpha-1 selective agonists
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Methoxamine
Phenylephrine |
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direct acting alpha-2 selective agonists
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Clonidine
Brimonidine Tizanidine these are direct acting & produce CNS effects |
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mostly alpha agonists
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Phentermine
Ergot alkaloids |
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alpha=beta-1 >> beta-2 agonist
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norepinephrine
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mostly indirect mixed agonists
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Amphetamine
Methamphetamine Methylphenidate |
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purely indirect mixed agonist
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Tyramine
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beta-1 selective agonist
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Dobutmine
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beta-2 selective agonists
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Albuterol
Levalbuterol Salmeterol |
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beta agonist (both beta-1 and beta-2)
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Isoproterenol
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DA receptor > beta > alpha agonist
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Dopamine
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indirect acting alpha-2 receptor agonist
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alpha-methyl-NE (the metabolite of Methyldopa)
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TRUE OR FALSE
BOTH Epinephrine and Norepinephrine activate alpha-1 and alpha-2 receptors. |
True
Norepinephrine, when acting on alpha-2 receptors, inhibits its own release. |
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Epinephrine activates both beta-1 and beta-2 receptors. What about Norepinephrine? Does it activate both as well?
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Nope. Norepinephrine is more selective for beta-1.
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Drugs that inhibit catecholamine uptake produce (sympathomimetic/sympatholytic) effects.
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sympathomimetic
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Drugs that inhibit MAO's produce (sympathomimetic/sympatholytic) effects.
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sympathomimetic
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Amphetamine & Methylphenidate
Much of their action is due to (blank) release. |
Much of their action is due to NE release.
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Tyramine is a pure (indirect/direct) acting agonist.
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indirect
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There are mixed alpha=beta direct agonists. Name them.
There are mixed alpha=beta indirect agonists. Name them. |
Direct: Epinephrine, Ephedrine, Pseudoephedrine, Dopamin
Indirect: Amphetamine, Methylphenidate, Tyramine |
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These 2 alpha agonists have direct activity but also have CNS activity.
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Ergot alkaloids
Phentermine |
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Used to treat obesity and has CNS activity
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Phentermine
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This alpha-1 agonist is used in hypotensive emergencies.
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Methoxamine
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Epinephrine, Dobutamine, Isoproterenol are all used as cardiostimulants.
Which of the 3 would not be used in the case of shock? |
Isoproterenol. It is a pure beta agonist (thus a vasodilator) and would exacerbate the already decreased BP seen in shock patients.
Epinephrine, Dobutamine & Dopamine are all used in the treatment of shock. |
