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13 Cards in this Set
- Front
- Back
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Neurotrauma
Outline Incidence |
Haemorrhage
Cerebral Oedema Increased ICP Males 15-24yrs |
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Pathophys
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Ischaemia>cell hypoxia>Mitoch failure>mito Ca2+ sequest>Ca2+ overload>Free rad>Cell death.
Also - UP glut. release>open NMDA>cell death. Reperfusion>Immune cells>cell death. |
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Neurotrauma treatment
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Anti-ischaemics
heparin, warfarin anti-platelets Neuroprotectants Mg2+ - block NMDA ch. Block glutamate |
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Define Stroke
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Cerebrovascular accident
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Differentiate between stroke types
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Ischaemic
Haemorrhagic |
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Ischaemic stroke pathophys.
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- Thrombolytic or embolytic
Most common Usually better recov. than haem. Infarct & necrosis Zone around may be viable Sudden blockage and ox dep. Injury depends on length of ox dep. |
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Haemorrhagic
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structural abnormalities
hypertension increased ICP mmg symptoms. |
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Parkinsons
call pathophysiology |
Mitochondrial dysfunction
inhib of mito complex 1 of the ETC oxidative stress excitotoxicity inflammation and glial cell activation apoptosis |
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Why is Parkinsons pathology selective for dopamine neurons?
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Dopamine metabolism itself produces Free radicals --> damage
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Parkinsons - Which region of the bain?
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DA neurons in the Substantia nigra in constant ox stress
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Parkinson treatment - future directions
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neuroprotectants:
ROS scavengers |
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Parkinsons Animal models:
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MPTP actively & selectively taken up by dopaminergic neurons. accumulates. Induces nirgostriatal cell death
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NSAIDS in parkinsons:
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COX inhibition
limits free rad prod. anti inflamm antiapoptotic inhibits activation of antiapoptotic genes |
