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209 Cards in this Set
- Front
- Back
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reserpine
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blocks transporters for all biogenic amines (DA, NE, serotonin, histamine)
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tetrahydrobenazine
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blocks VDATs, less expensive than reserpine
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oubain
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inhibits synaptic DATs, blocks NA and K ATPases
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indantraline
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blocks DA, NE and 5HT transporters, sometimes prescribed to cocaine addicts, reuptake inhibitor
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cocaine
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blocks DA, NE and 5HT transporters, reuptake inhibitor
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bupropion
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wellbutrin, reuptake inhibitor, antidepressant, blocks transporters for DA and NE
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nomifesine
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meritol, reuptake inhibitor, blocks DATs
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duloxetine
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cymbalta, reuptake inhibitor, blocks DATs
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amphetamine
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fairly specific at blocking reuptake of DA, increases the amount of DA in the synapse
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dextroamphetamine
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amphetamine analog
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methylphenidate
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ritalin, increases activity in frontal lobe and has an inhibitory effect on NS, amphetamine analog
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MTPT
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byproduct of some synthetic opiates, DA specific neurotoxin, it is acted upon by glial cels converted to MPP which is taken into mitochrondria, blocks CREB cycle and kills cells, Parkinsons
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6-OH-DA
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taken into mitochondria, blocks CREB cycle and kills DA neurons
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dopamine
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DA agonist, all five receptors, prefers D5, activates some NE receptors
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lisuride
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DA agonist, all five receptors, alpha and beta, anti-parkisons
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apomorphine
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DA agonist, all five receptors, anti-parkinsons
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dihydrexidine
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anti-parkinsons, D1 preferably and D5, DA agonist
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fenoldopam
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anti-hypertensive, vasodilator, D1 only, does not cross BBB, DA agonist
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quinpirole
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anti-parkinsons, D2 and D3, DA agonist
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bromocriptine
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anti-parkinson, D2, D3, D4 DA agonist
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pergolide
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D2,D3,D4 DA agonist
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pramipexole
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mirapex, restless leg syndrome, D2 and D3, prefers D3, DA agonist
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ropinirole
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requip, restless leg syndrome, D2,D3, prefers D3, DA agonist
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spiperone
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all five DAR antagonist especially D1. slective 5HT1a antagonist
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ecopipam
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D1 and D5, DAR antagonist
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domoperidone
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D2, D3 and D4 DAR antagonist
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amisulpride
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D2 and D3, prefers D2, antipsychotic, DAR antagonist
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chlorpromazine
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D2-D4, neuroleptic drug, used almost exclusively for schizophrenia, most are older drugs, in extreme doses has a sedative effect, DAR antagonist
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triflupenazine
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D2-D4, neuroleptic, still widely prescribed, DAR antagonist
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piperazine
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D2-D4, neuroleptic, DAR antagonist
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risperidone
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D2-D4, neuroleptic, still widely prescribed, DAR antagonist
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clozapine
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D4, atypical, does not effect the classic autoreceptors but does have beneficial effects for some pateints, maybe some of their D4 receptors. DAR antagonist
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guanethedine
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cross the BBB, used to control BP, blocks VNETs
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guandrel
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used to control BP, blocks VNETs
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bretylium
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cross the BBB, used to control BP, blocks VNETs
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venlafaxine
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effexor, blocks NE and 5HT reuptake
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clomipramine
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treas anxiety, NE and 5HT reuptake blocker
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imipramine
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tricyclic, NE reuptake blocker
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amitripyline
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tricyclic, NE reuptake blocker
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viloxazine
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atypical antidepressant, NE reuptake blocker
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atomazetine
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straterra, for ADD, less amphetamine effects, NE reuptake blocker
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befloxatone
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reversible A-specific MAO inhibitor
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clorgyline
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irreversible A-specific MAO inhibitor
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harmaline
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irreversible a-specific MAO inhibitor
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iproniazid
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irreversible non-specific MAO inhibitor
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deprenyl
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irreversible b-specific MAO inhibitor, in phase 3 treatment of AD, breaks down histamine
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selegiline
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irreversible b-specific MAO inhibitor
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tolcapone
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irreversible COMT inhibitor
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phenylephrine
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nonselective agonist for alpha1A, 1B, 1D adrenoceptors
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ephedrine
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nonselective agonist for alpha1A,, 1B, 1D adrenoceptors, hallucinogenic relative of NE
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tetrahydrazoline
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selective agonist for alpha1a, 1d adrenoceptors, major ingredient in eyedrops
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niguldipine
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selective antagonist for alpha1a adrenoceptors, relaxes blood vessels
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phentolamine
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nonselective antagonist for alpha1a, 1b,2a,2b,2c adrenoceptors
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prozosin
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nonselective antagonist for alpha1a,1b,2a,2b,2c adrenoceptors
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phenoxbenzamine
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suicide antagonist for alpha1a, 1b adrenoceptors
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cyclozasin
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selective antagonist for alpha1a adrenoceptors
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pseudoephedrine
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interacts with alpha1d receptors, decongestant
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clonidine
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nonselective alpha2a,2b adrenoceptor antagonist
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oxymetazoline
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selective alpha2a adrenoceptor partial agonist
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LSD-25
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selective alpha2A adrenoceptor partial aognist, hallucinogenic relative of NE, ergot derivative, selective 5HT1,5HT2a,c partial agonist
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yohimbine
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nonselective alpha2a,2b,2c adrenoceptor antagonist, hallucinogenic relative of NE
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imiloxon
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alpha2b adrenoceptor selective antagonist
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rauwolscine
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alpha2c adrenoceptor selective antagonist
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phentolamine
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antihypertensive agent, natural treatment for ED but must be injected directly into organ
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phenylethylamine
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hallucinogenic relative of Ne, found in chocolate
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cathine
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hallucinogenic realtive of Ne
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mescaline
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hallucinogenic relative of Ne
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elimicin
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hallucinogenic relative of NE found in nutmeg
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MDMA
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hallucinogenic relative of NE
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estrogen
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gonadal steroid
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androgen
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gonadal steroid
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progesterone
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gonadal steroid
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estradial
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endogenous estrogen agonist
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estiol
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endogenous estrogen agonist
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estrone
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endogenous estrogent agonist
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clomiphene
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estrogen antagonist
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tamoxifen
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estrogen antagonist
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testosterone
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endogenous androgen agonist
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DHT
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endogenous androgen agonist
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flutamide
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androgen antagonist
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mifepristone
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progesterone antagonist, glucocorticoid antagonist, morning after pill
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cortisol
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glucocorticoid endogenous agonist
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corticosterone
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glucocorticoid endogenous agonist
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aldosterone
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mineralocorticoid endogenous agonist
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spirvolctone
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mineralocorticoid antagonist
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premarin
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brand name, most widely used birth control pill, mix of all the estrogens
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ethimyl estradial
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combination monophasic birth control pill
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norethendrone
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progestin only birth control pill
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anastrozole
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maromatase inhibitor, prevents the aromatization of estrogen/testosterone to estrogen
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oxandrolone
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anabolic steroid similar to testosterone
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finasteride
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antiandrogen, used for treatment of sex offenders and treatment of prostate cancer, alpha-reductase inhibitor
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ketoconazole
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steroid synthesis inhibitor, enhances clearance, blocks adrenal and gonadal steroid biosynthesis
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metyrapone
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steroid synthesis inhibitors, blocks cortisol biosynthesis
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dronaminol
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THC in pill form, never actually came out on the market
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anadamide
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endogenous agonist for CB1 and CB2 cannabinoid receptors, produced by glial cells
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THC
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nonselective exogenous agonist for cannabinoid receptors
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DMT
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ergot derivative, hallucinogenic drug, 5HT1a,2a selective agonist
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DET
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ergot derivative, hallucinogenic
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psilocybin
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natural hallucinogen, selective 5HT1a,2a,2c partial agonist
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mescaline
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natural hallucinogen
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datura
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natural hallucinogen
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DOM-STO
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hallucinogenic amphetamines, 5HT2a selective agonist
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MDA
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hallucinogenic amphetamines
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2-CB
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hallucinogenic amphetamines
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betamethason
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clinical corticosteroid
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dexmethasone
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synthetic form of hydrocortisone, corticosteroid
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prednisone
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clinical corticosteroid
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acetaminophen
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NSAID, target COX1 and 2
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ibuprofen
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NSAID, target COX1 and 2
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naproxen
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NSAID, target COX1 and 2
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celecoxib
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celebrex, COX2 inhibitor
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beta-endorphin
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mu opiate receptor endogenous agonist
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morphine
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my opiate receptor selective exogenous agonist, organic opium alkaloid
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cyprodime
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mu opiate receptor selective antagonist
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leu-enkephalin
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delta opiate receptor endogenous agonist
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met-enkephalin
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delta opiate receptor endogenous agonist
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deltorphin
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delta opiate receptor endogenous agonist
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dynorphin
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kappa opiate receptor endogenous agonist
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nociciptin/ophanin
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ORL1 opiate receptor endogenous agonist
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naloxone
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nonspecific antagonist of opiate receptor, overdose treatment
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naltrexone
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nonspecific antagonist of opiate receptor, overdose treatment
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dprenorphine
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nonspecific antagonist of opiate receptor
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narcotine
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organic opium alkaloid
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papverine
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organic opium alkaloid
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thebaine
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organic opium alkaloid
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codeine
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organic opium alkaloid
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oxycodone
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percodan, oxycontine, modified opiates
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diacetylmorphine
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heroin, modified opiate
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hydromorphine
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dilaudid, modified opiate
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hydrocodone
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vicodin, modified opiate
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fentanyl
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synthetic opiate, used in surgical procedures, clears the body in 30-45mins
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meperidine
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demerol, synthetic opiate
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propexyphene
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darvon, synthetic opiate
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bprenophrine
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synthetic opiate, buprenex, partial agonist, high affinity for mu receptors
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methadone
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helps come down from opiates, synthetic opiate
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haloperidol
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sigma opiate receptor
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pentazocine
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sigma opiate receptor
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ifenprodil
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sigma opiate receptor
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nitrous oxide
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volatile anesthetic
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diethyl ether
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voltaile anesthetic
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chloroform
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volatile anesthetic
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isoflurane
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volatile anesthetic
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sevoflurane
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volatile anesthetic
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ketamine
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dissociative anesthetic
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dextromethorphan
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dissociative anesthetic
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PCP
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dissociative anesthetic
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citalopram
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celexa, SSRI antidepressnant
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paroxetine
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paxil, SSRI antidepressant
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sertrilline
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zoloft, SSRI antidepressant
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fluvoxamine
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luvox, SSRI, OCD/anxiolytic
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carbidopa
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MAO inhibitor, blocks AAADC
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fenfluromine
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blocks TryOHase, MAO inhibitor
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disulfrem
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MAO inhibitor blocks aldehyde dehydrogenase
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serotonin
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ubiquitous serotonin receptor agonist
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quipazine
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ubiquitous serotonin receptor agonist
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buspirone
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selective 5HTa full agonist, anxiolytic
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DPAT
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selective 5HTa full agonist
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bufotenin
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selective 5HT1a full agonist, from toads
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ergotamine
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selective 5HT1b and 1d full agonist, facial and cerebral vasoconstrictor
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methysergide
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selective 5HT1b and 1d full agonist, rye mold, taken in large doses by adolf hitler, throught to control migraines, facial and cerebral vasoconstrictor, 5HT2c selective antagonist, 5HT6 and 7 partial agonist
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sumatripan
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selective 5HT1b and 1d full agonist, synthetic migraine treatment
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isomoltane
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selective 5HT1b and 1d antagonist
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methiothepin
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selective 5HT1e and 1f antagonist
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pindolol
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nonselective 5HT antagonist, 5Ht1
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alpha-me-5HT
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nonselective 5HT2 agonist
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DOI
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selective 5HT2a agonist
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phenylethylamine
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5HT2a partial agonist
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agonelatine
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5HT2c selective agonist, no hallucinogenic properties
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ketaserin
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5HT2a selective antagonist
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metergoline
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5HT2b selective antagonist
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ritonserin
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5HT2c selective antagonist
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mesulergin
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5HT2 nonselective antagonist
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dibenzyline
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5HT2 nonselective antagonist
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CBG
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5HT3 selective agonist
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2-me-5HT
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5HT3 selecitve agonist
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ondansetron
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zofran, antiemetic, nootropic, 5HT3 selective antagonist
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zacopride
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antiemetic, nootropic, 5HT3 selective antagonist
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alestron
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treatment of IBS, 5HT3 selective antagonist
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8-OH-DPAT
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5HT7 partial agonist
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COAT
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5HT7 selective agonist
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EMDT
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5HT6 selective agonist
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CTST
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5HT6 selective agonist
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amoxipine
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5HT6 selective antagonist
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clozapine
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5HT6 and 7 nonselective antagonist
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PCPA
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neurotoxin that interferes with oxidative metabolism, kills 5HT cells in mitochondria through disruption of CREB cycle
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brocresine
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blocks HA decarboxylase and histamine synthesis, crosses BBB
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tacrine
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blocks the breakdown of HA by blocking histamine methyltransferase, also blocks AChE, AD treatment
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metoprine
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blocks the breakdown of HA by blocking histamine methyltransferase
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histamine
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HA agonist 1-4
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histaprodifen
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HA agonist, H1
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dimaprit
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H2, stimulates H2 receptors, Ha agonist
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imetit
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H3 and H4, HA agonist
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proxyfan
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HA agonist, crosses BBB partial agonist H3
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clobenprofit
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stimulates H4 agonist HA
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chlorpheniramine
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cross BBB, causes sleepiness, in OTC drugs, antihistamine competitive H1 antagonist
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diphenhydramine
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benadryl, antihistmine, H1 antagonist, cross BBB
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cetirizine
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zyrtec, antihistamine, H1 antagonist
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cyclizine
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antihistamine, H1 antagonist
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loratadine
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claratin, antihistamine H1 antagonist, supposed to be non-drowsy
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fexofenadine
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allegra, antihistamine H1 antagonist, supposed to be non-drowsy
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dimenhydrinate
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dramamine, anti-emetic, H1 antagonist
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mecilzine
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antiemetic, H1 antagonist
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promethazine
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antiemetic, H1 antagonist
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triprolidine
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anti-allergy, H1 antagonist
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cimetidine
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H2 competitive antagonist, H2 tagamet
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ranitidine
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H2 competitive antagonist, zantac
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clobenpropit
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H3 competitive antagonist
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thioperamide
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H3 and H4 competitive antagonist
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tiotidine
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H2 inverse agonist, causes a decrease in the acid signal
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