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20 Cards in this Set
- Front
- Back
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What is the half-life of fluoxetine?
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up to 5 weeks because of the long action of nor-fluoxetine
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What is the half life of non-selective mao inhibitors such as hydrazine?
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2 to 3 weeks
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What is the interaction between tricyclic antidepressants and SSRI?
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SSRI can actually decrease the metabolism of TCA leading to toxicity
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What is the fatal side effect that can occur with TCA toxicity?
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cardiac depression, cardiac arrhythmias, QT prolongation
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What populations of patients are not optimal for TCA treatment?
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elderly pt. can develop edema, postural hypotension, dizziness, sedation, pt. with cardiac disease, suicidal patients, severely depressed pt.
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What drug combinations have been shown to lead to serotonin syndrome?
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SSRI, MAO-I, demerol, cocaine, amphetamines, fenfen, dextromethorphan, linezolid, serotonin agonists like triptans
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What is hypertensive crisis and why does it occur with MAO inhibitors?
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hypertensive crisis results because hepatic MAO is necessary to metabolize dietary amines such as tyramine found in food; if non-selective MAO such as MAO-A action can lead to hypertensive crisis and fatal hemorrage, always worry about pt. on MAO-i with new onset headache or hypertension
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What is the main adverse effect of trazodone?
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priapism because of the anti-adrenergic effect
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What is the main adverse effect of SSRI?
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drug interactions with CYP 450 (benzos, warfarin, theophylline, TCA); nausea/vomiting, activation, akathisa, mania, sexual dysfunction; interactions with other meds
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What dose of buproprion can lead to seizures?
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more than 450 mg/day
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What symptoms occur because of MAO inhibitor overdosage?
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agitation, hallucinations, hyperreflexia, fever and convulsions
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What are the side effects of tricyclic antidepressants?
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orthosatic hypotension, dry mouth, sour test, epigastric distress, constipation, tachycardia, palpitations, blurred vision, ur retention
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What is the adverse reaction associated with nefazodone?
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hepatotoxicity
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What is important to know about metabolism of SSRI in young childrenn and older patietns?
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young children metabolize more rapidly and older patients metabolize more slowly
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What are some withdrawal syndromes that may occur with SSRI discontinuation?
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GI, paresthesias, irritability (esp. paroxetine and effexor); discontinue over 1 week
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What is a withdrawal syndrome which may occur with abrupt discontinuation of TCA?
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malaise, chills, coryza, muscle aches, sleep disturbance
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What are the withdrwal reaction that may occur with discontinuation of the MAO inhibitors?
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nausea, vomiting, malaise, nightmares, agitation, psychosis and convulsions
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Which antibiotics have been associated with lowering the seizure threshold?
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carbapenems, penicillins, metronidazole, isoniazid, fluoroquinolones
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What are the side effects of etanercept and TNF inh drugs?
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it can cause demyelinating lesions
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What are the most common peripheral nervous system abnormalities to develop after CABG?
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brachioradiculoplexopathies
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