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19 Cards in this Set
- Front
- Back
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is there an inc or dec in metabolic activity when there is direct damage to the cell body of a neuron?
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-increase
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what are often generated during CNS damage?
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-oxygen free radicals
-they can cause peroxidation of cell membranes that can adversely alter the properties of those membranes |
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what happens during alzheimers?
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-AAA (aphasia, agnosia, apraxia)
-neurofibrillary tangles -amyloid bodies |
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what happens in parkinsons?
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-degeneration of SN leads to dec DA in striatum
-temor, rigidity, bradykinesia |
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what happens in amyotrophic lateral sclerosis?
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-mixed UMN and LMN disease
-degeneration of alpha motor neuron in SC and BST motor nuclei |
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what nuclear changes occur during apoptosis?
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-chromatin condensation
-nuclear fragmentation |
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what regulates the apoptotic process?
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-a caspase cascade
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what happens during chromatolysis?
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-hypertrophy of CB
-eccentric location of nucleus -nissl is dispersed -protein synthesis increases |
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neurapraxia
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-nerve damage with no interruption of the nerve or its sheath
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axonotmesis
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-disruption of the axon without rupturing the myelin sheath
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neurotmesis
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-both neuronal and myelin sheath are ruptured
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which direction is wallerian degeneration?
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-anterograde
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what happens in guillain-barre syndrome?
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-segmental demyelination
-proximal weakness -no sensory involvement |
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agrin
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-proteoglycan that promotes functional synapse formation
-made by motor neurons |
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what happens when agrin binds to its receptor?
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-leads to a clustering of ACh receptors and to synaptogenesis
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what does neuronal regeration imply?
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-regrowth of damaged nerve fibers
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totipotent cell
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-can become any type of cell in the body
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pluripotent cell
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-can develop into many different types of cells
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what type of cells have the best potential for human therapies?
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-pluripotent
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