Neuromuscular Junction Blockers & Local Anesthetics

Front 1

Atracurium

Back 1

s

Front 2

Mivacurium
a.) class
b.) derivative
c.) duration
d.) metabolism
e.) C/I

Back 2

Mivacurium
a.) non-depolarizing NMJ blocker; GA adjunct
b.) benzylisquinoline
c.) short duration (12-18 minutes)
d.) plasma cholinesterases (thus short duration)
e.) pts with liver dysfunction

Front 3

Pancuronium

Back 3

s

Front 4

Succinylcholine

Back 4

j

Front 5

Bupivacaine
a.) class
b.) pk
c.) main indication (1); other indications (3)
d.) ADR main

Back 5

Bupivacaine
a.) amide local anesthetic
b.) long duration of action
c.) labor analgesia bc its a sensory block not a motor block
d.) cardiotoxicity if used IV

Front 6

Lidocaine
a.) class
b.) pk
c.) comparison

Back 6

Lidocaine
a.) Amide local anesthetic
b.) high diffusion and penetration
c.) most used local anesthetic

Front 7

Ropivacaine
a.) drug class
b.) unique characteristic
c.) pk/comparison
d.) indication

Back 7

Ropivacaine
a.) amide local anesthetic
b.) pure enantiomer, so less CNS and cardiotoxicity
c.) less lipophilic than bupivacaine, so less effect on motor neurons
d.) labor analgesia

Front 8

Articaine
a.) drug class
b.) indication
c.) pk/metabolism

Back 8

Articaine
a.) amide local anesthetic
b.) dental anesthesia
c.) rapidly metabolized via carboxyesterase so that only 5-10% gets metabolized in the liver. Safer than prilocaine

Front 9

Benzocaine
a.) class
b.) indication
c.) characteristic
d.) ADR (rare)

Back 9

Benzocaine
a.) ester local anesthetic
b.) surface anesthesia
c.) lower water solubility, poor absorption
d.) methemoglobin; generally non-toxic

Front 10

Cocaine Hydrochloride
a.) class
b.) unique property
c.) ADR general/ (3)

Back 10

Cocaine Hydrochloride
a.) ester local anesthetic
b.) the only LA with vasoconstrictive properties
c.) low toxicity if applied locally; nervousness, convulsions, cardiac failure

Front 11

Rocuronium
a.) class
b.) derivative
c.) duration
d.) indication

Back 11

f