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16 Cards in this Set
- Front
- Back
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dantroline function
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block calcium help with muscle spasm and malignant hyperthermia
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neostigmine
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competitively blocks effects of acetylcholinesterase so non-depolarizing drugs will not be broken down
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antidote for depolarizing drugs
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none
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malignant hyperthermia and antidote
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caused by rapid buildup of Ca2+ in muscle from gas anesthetics and succ. causes rigitiy, hyperthermia, tachycardia, mortality and acidosis
antidote is dantrolene |
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antispastic drugs
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diazepam
baclofen dantrolene |
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dantrolene
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interferes with intracellular release of Ca ions
most effective with spasticity of cerebral origin can be hepatotoxic |
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tubocurare
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releases histamine, causes hypotension, binds to ganglionic receptors,
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atracurium
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non-depolarizing blocker, undergoes spontaneous breakdown, can cause seizures, but few cardiac side effects,
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pancuronium
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non-depolarizing blocker, some antimuscarinic/anticholinergic effects, cause increased HR, increased release of NE
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succinylcholine
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depolarizing drug, lasts 15 min, chewed up by pseudocholinesterase,
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fasciculations and non-depolarizing drugs
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no action potential is generated so you should never get fasciculations with a non-depolarizing drug
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dantrolene
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used to treat malignant hyperthermia
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rocuronium
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blocks neuromuscular channels
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diazepam mechanism
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augments chloride channel influx and will make cell very negative and difficult to depolarize which will reduce spasms
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baclofen mechanism
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opens potassium channels allowing potassium to rush out of cell making it more negative and harder to depolarize
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dantrolene mechanism
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blocks calcium from being released at sarcoplasmic reticulum in muscles
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