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28 Cards in this Set
- Front
- Back
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What are Lipofuscin granules?
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Pigmented cytoplasmic inclusions that commonly accumulate with aging. They are considered residual bodies that are derived from lysosomes
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Where in the cell are lipofuscin granules located?
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The cytoplasm
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What pigment/inclusion accumulates with age?
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Lipofuscin granules
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What pigment/inclusion are considered residual bodies that are derived from lysosomes?
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Lipofuscin granules
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Where are lipofuscin granules derived from?
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Lysosomes
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What in melanin (neuromelanin)?
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Melanin is blackish intracytoplasmic pigment found in the substantia nigra and locus coeruleus. It disappears from nigral neurons in patients who have Parkinson's disease
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Where in the brain is melanin found?
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Substantia nigra and locus coeruleus
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Which patients lose neuromelanin?
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It disappears from nigral neurons in patients with Parkinson's disease
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Where in the cell is melanin found?
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The cytoplasm
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What pigment/inclusion is found in the substania nigra and locus coeruleus?
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Melanin (neuromelanin)
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What are Lewy bodies?
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Neuronal inclusions that are characteristic of Parkinson's disease
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What pigment/inclusions are characteristic of Parkinson's disease?
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Lewy bodies
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What are Negri bodies?
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Intracytoplasmic inclusions that are pathognomonic of rabies. They are found in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum
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What pigment/inclusion is pathognomonic of rabies?
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Negri bodies
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Where are negri bodies found in the brain?
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The pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum
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Where in the cell are negri bodies found?
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Cytoplasm
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What pigment/inclusion is found in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum?
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Negri bodies
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What are Hirano bodies?
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Intraneuronal, eosinophilic, rodlike inclusions that are found in the hippocampus of patients with Alzheimer's disease
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What pigment/inclusion is associated with Alzheimer's disease?
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Hirano bodies
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What pigment/inclusion is an eosinophilic, rod-like inclusion?
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Hirano bodies found in Alzheimer's patients
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Where in the brain are Hirano bodies found?
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Hippocampus
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Describe neurofibrillary tangles
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Consist of intracytoplasmic degenerated neurofilaments. They are seen in patients with Alzheimer's disease
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Where in the cell are neurofibrillary tangles seen?
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In the cytoplasm
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What pigment/inclusion is associated with Alzheimer's disease
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Hirano bodies and neurofibrillary tangles
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What are Cowdry type A inclusion bodies?
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Intranuclear inclusions that are found in neurons and glia in herpes simplex encephalitis
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Where in the cell are Cowdy type A inclusion bodies found?
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Intranuclear
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Where are Cowdy type A inclusion bodies found?
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In neurons and glia
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What pigment/inclusion is assocaited with herpes simplex encephalitis?
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Cowdy type A inclusion bodies
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