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5 Cards in this Set
- Front
- Back
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Myasthenia Gravis - what is it?
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Weakness due to a defect of neuromuscular transmission of acetylcholine
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MG - what causes the defect in neuromuscular transmission?
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- Autoantibodies directed against nicotinic ACh receptors on post-synaptic skeletal muscle.
- usually against binding site for ACh (alpha subunit) |
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MG - role of thymus?
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- Thymic T cells probably augment B-cell production of autoantibodies.
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MG - three other autoimmune diseases associated with MG
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1. Graves' Disease
2. collagen-vascular disease 3. pernicious anemia |
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MG - cardinal clinical sign
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- FATIGABLE weakness
- (i.e. patient's strength decreases with successive muscle contractions) |
