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5 Cards in this Set

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  • Back
Myasthenia Gravis - what is it?
Weakness due to a defect of neuromuscular transmission of acetylcholine
MG - what causes the defect in neuromuscular transmission?
- Autoantibodies directed against nicotinic ACh receptors on post-synaptic skeletal muscle.
- usually against binding site for ACh (alpha subunit)
MG - role of thymus?
- Thymic T cells probably augment B-cell production of autoantibodies.
MG - three other autoimmune diseases associated with MG
1. Graves' Disease
2. collagen-vascular disease
3. pernicious anemia
MG - cardinal clinical sign
- FATIGABLE weakness
- (i.e. patient's strength decreases with successive muscle contractions)