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37 Cards in this Set

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Lithium
-Used for bipolar
-Side effects: GI, alopecia, weight gain, ataxia, acne, polyuria, polydipsia, Ebstein's anomoly.
-Most drugs elevate lithium levels (except caffeine)
-Elevates TSH *
-"Water faucet to water closet"
Thioridazine (Melaril)
-Side effects: Arrhythmias, retrograde ejaculation, pigmentary retinopathy
Clozapine (Clozaril)
-Atypical antipsychotic
-Side effects: sialorrhea, agranulocytosis*, seizures, cardiomyopathy
-"biggest gun" for hallucinations
Trazodone (Desyrel)
-inhibits 5HT reuptake, inhibits alpha-1 receptor on vessels causing dilation
-Side effects: priapism, orthostatic hypotension
Compare with Midodrine (alpha-1 agonist)
Uremic polyneuropathy
axonal mixed sensorimotor polyneuropathy
Lead
Encephalopathy in children
Demyelinating polyneuropathy (motor) with preference for radial nerve
Arsenic
Demyelinating polyneuropathy (motor)
Abdominal pain, anemia, jaundice
Encephalopathy
Thalium
Demyelinating polyneuropathy (sensory)
Optic atrophy and ophthalmoplegia
*Alopecia
Can get alopecia with lithium as well
Mercury
Bilateral basal ganglia dysfunction
Movement disorder associated with biliary excretion problems
Pilocarpine
-Muscarinic agonist (Ach)
-Parasympathomimetic
-pupillary constriction
Opposite of atropine (muscarinic antagonist)
Nucleus basalis
Nucleus where Ach is made
Nucleus Accumbens
Nucleus associated with addiction and Dopamine
Cocaine inhibits Dopamine reuptake
Raphe nucleus and Serotonin
Mediates NREM sleep
Nefazodone
Increases REM
Locus Ceruleus and sleep stage
Location that initiates REM
Vigabatrin
-Inhibits GABA transaminase therefore increasing GABA.
-bi-Nasal VF abnormalities
Mitazapine (Remeron)
-Atypical antipsychotic
-5HT2A and Histamine H1 blocker
-Same as Olanzapine/Clozapine
Baclofen and PAN
Improves PAN (Periodic Alternating Nystagmus)
Capsaicin
VA1 receptor
Causes release of substance P
-involved in pain modulation
Ropinirole (Requip)
Pramipexole (Mirapex)
-Dopamine agonists used in PD
-Can cause sudden attacks of sleep while driving.
Midodrine
-Used to treat orthostatic hypotension
-alpha-1 adrenergic agonist (NE) causing vasoconstriction
Compare to trazodone (alpha-1 antagonist)
Sumatriptan (Imitrex)
Agonist of 5HT1D causing vasoconstriction
Odansetron (Zofran)
Ligand of 5HT3 receptor (antagonist)
-treat nausea
Phenytoin (Dilantin)
1/2 life=22 hours
-Reduces post-tetanic potentiation
-Causes lymphadenopathy, ataxia, rash, gingival hyperplasia, hirsuitism, vermian atrophy
-Na channel blocker
Valproate (Depakote)
1/2 life=14 hours
Side effects: allopecia, wt gain
-Na channel blocker
Carbamazepine (Tegretol)
1/2 life=12 hours
Side effects: diplopia, ataxia, hyponatremia, rash, liver dysfunction, dyscrasias
-Na channel blocker
Ethosuximide (Zarontin)
1/2 life=40 hours
Side effects: Nausea, lethargy, headache, rash
-Ca channel blocker (T-type)
-Treat absence seizures
Lamotrigine (Lamictal)
1/2 life=24 hours
-side effects: rash, Stevens Johnson, elevated epoxide, ataxia
-Voltage-gated Na channel blocker
Topiramate (Topamax)
1/2 life=22 hours
-side effects: somnolence, confusion, word-finding difficulty, paresthesias, angle closure glaucoma, kidney stones, myopia
-Na channel blocker
Felbamate (Felbatol)
1/2 life=20 hours
Side effects: bone marrow failure (1/3000), liver failure, wt loss, GI complaints
-Glutamate-receptor glycine blocker
Compare to domoic acid (amnestic shellfish poison that activates glutamate/kainate receptors causing seizure)
Clonazepam (Klonopin)
1/2 life=30 hours
Cisplatinum
Encephalopathy
Ototoxicity
Cerebellar findings
Renal problems
Autonomic & peripheral neuropathy
5-FU
acute cerebellar syndrome
cranial neuropathy
disorientation/confusion
seizures
Cytarabine (Ara-C)
cerebellar dysfunction
somnolence/confusion
personality change
peripheral neuropathy
rhabdomyolysis *
myelopathy *
Methotrexate
Leukoencephalopathy *
myelopathy
chemical arachnoiditis if intrathecal
Tamoxifen
decreased visual acuity
Vinblastine
autonomic neuropathy
cranial neuropathy (same as 5-FU)
muscle pain