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25 Cards in this Set
- Front
- Back
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Metabotropic neurotransmission
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-binding of NT to receptor alters biochemical processes in the recipient cell
-responses are late onset and long duration |
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What are the 4 major conformations of G protein receptors in the brain?
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-Gs
-Gi -Gq -Go |
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Gs
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-inc adenylate cyclase activity
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Gi
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-dec adenylate cyclase activity
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Gq
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-inc phospholipase c activity
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Go
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-inc the activity of Ca2+ and K+ channels
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cAMP
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-2nd messenger
-cyclic nucleotide gated ion channels -PKA |
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DAG
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-2nd messenger
-PKC |
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IP3
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-2nd messenger
-targets receptors on ER |
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Ca2+
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-2nd messenger
-PKC -Calmodulin -CaMK |
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What are the fns of the subtypes of dopamine receptors?
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-D1/D5 inc adenylyl cyclase
-D2/D3/D4 dec adenylyl cyclase |
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What are the fns of NE receptor subtypes?
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-alpha1 inc phospholipase C
-alpha2 dec adenylyl cyclase -beta inc adenylyl cyclase |
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What are the fns of ACh receptor subtypes?
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-nic is Na+/K+ conductance
-m1/m3/m5 inc phospholipase C -m2/m4 dec adenylyl cyclase |
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What are the fns of GABA receptor subtypes?
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-A Cl- conductance
-B K+/Ca2+ conductance |
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What are the fns of Glutamate receptor subtypes?
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-AMPA does Na+/K+ conductance
-NMDA does Ca2+ conductance -Metabotropic inc phospholipase C |
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what enzyme catalyzes ACh synthesis?
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-choline acetyltransferase
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what enzyme catalyzes ACh breakdown?
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-acetylcholinesterase
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How do catecholamines effect behavior in general?
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-inc catecholamines leads to excitation of behavior
-dec catecholamines leads to depressed behavior |
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Neuroleptic
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-antipsychotic
-blocks catecholamine receptors |
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Reserpine
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-antipsychotic
-blocks NT uptake into vesicles |
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Tricyclic antidepressant (imipramine)
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-antidepressant
-blocks catecholamine reuptake fromt the synaptic cleft |
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MAO inhibitor
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-antidepressant
-inhibits MAO |
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Amphetamine
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-stimulant/antidepressant
-inhibits MAO -inhibits reuptake from cleft -causes catecholamine release |
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what enzyme breaks down 5HT?
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-MAO
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What is 5HT functionally involved in?
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-the regulation of sleep and wakefullness
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