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25 Cards in this Set

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  • Back
Metabotropic neurotransmission
-binding of NT to receptor alters biochemical processes in the recipient cell
-responses are late onset and long duration
What are the 4 major conformations of G protein receptors in the brain?
-Gs
-Gi
-Gq
-Go
Gs
-inc adenylate cyclase activity
Gi
-dec adenylate cyclase activity
Gq
-inc phospholipase c activity
Go
-inc the activity of Ca2+ and K+ channels
cAMP
-2nd messenger
-cyclic nucleotide gated ion channels
-PKA
DAG
-2nd messenger
-PKC
IP3
-2nd messenger
-targets receptors on ER
Ca2+
-2nd messenger
-PKC
-Calmodulin
-CaMK
What are the fns of the subtypes of dopamine receptors?
-D1/D5 inc adenylyl cyclase
-D2/D3/D4 dec adenylyl cyclase
What are the fns of NE receptor subtypes?
-alpha1 inc phospholipase C
-alpha2 dec adenylyl cyclase
-beta inc adenylyl cyclase
What are the fns of ACh receptor subtypes?
-nic is Na+/K+ conductance
-m1/m3/m5 inc phospholipase C
-m2/m4 dec adenylyl cyclase
What are the fns of GABA receptor subtypes?
-A Cl- conductance
-B K+/Ca2+ conductance
What are the fns of Glutamate receptor subtypes?
-AMPA does Na+/K+ conductance
-NMDA does Ca2+ conductance
-Metabotropic inc phospholipase C
what enzyme catalyzes ACh synthesis?
-choline acetyltransferase
what enzyme catalyzes ACh breakdown?
-acetylcholinesterase
How do catecholamines effect behavior in general?
-inc catecholamines leads to excitation of behavior
-dec catecholamines leads to depressed behavior
Neuroleptic
-antipsychotic
-blocks catecholamine receptors
Reserpine
-antipsychotic
-blocks NT uptake into vesicles
Tricyclic antidepressant (imipramine)
-antidepressant
-blocks catecholamine reuptake fromt the synaptic cleft
MAO inhibitor
-antidepressant
-inhibits MAO
Amphetamine
-stimulant/antidepressant
-inhibits MAO
-inhibits reuptake from cleft
-causes catecholamine release
what enzyme breaks down 5HT?
-MAO
What is 5HT functionally involved in?
-the regulation of sleep and wakefullness