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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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which compounds have to be kept out of the brain?
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neuroactive compounds and neurotoxic compounds (excitory neurotransmitters can be neurotoxic in large doses)
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what can pass through the BBB?
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lipophilic (hydrophobic) and small molecules can pass through passively by dissolving in lipid component of BBB
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which compound are actively transported across BBB?
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d-glucose, phenylalanine and l-dopamine
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what don't brain capillaries have?
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fenestra
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what do brain capillaries have?
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tight junctions formed by endothelial cells and maintained by adjacent astrocytes
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what is HIV an example of?
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a large molecule that can pass through BBB even though large molecules normally can't
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what can damage/alter BBB? (6)
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-high BP
-infections (inflammatory response) -specific compounds (NAAG, Quinolinic acid) -brain tumors -MS -crain oedema (stroke, head injury) |
think blood, brain, disease
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how do desirable substances cross BBB (eg d-glucose, vitamins etc)?
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-active transport (fast)
d-glucose (not l), ess aacids -via CSF (slower than active transport) vitamins, hormones |
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how are drugs made to cross BBB?
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made more lipophilic through addition of aromatic component
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what is HIV an example of?
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a large molecule that can pass through BBB even though large molecules normally can't
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what can damage/alter BBB? (6)
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-high BP
-infections (inflammatory response) -specific compounds (NAAG, Quinolinic acid) -brain tumors -MS -crain oedema (stroke, head injury) |
think blood, brain, disease
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which parts of the brain have naturally low BBB?
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circumventricular organs; organum vasculosm of lamina terminals, area posrema (vomitting reflex)
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how do desirable substances cross BBB (eg d-glucose, vitamins etc)?
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-active transport (fast)
d-glucose (not l), ess aacids -via CSF (slower than active transport) vitamins, hormones |
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how are drugs made to cross BBB?
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-made more lipophilic through addition of aromatic component
-high intensity focused ultrasound (temporarily breaks down BBB) |
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