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5 Cards in this Set
- Front
- Back
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Risk factor for vCJD ( genetic )
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MM allele (methionine instead of Valine)
VV (normal) MM causes more protien protein interaction with infectious prion |
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prp (c) vs (sc)
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sc is bad (beta)
c is good alpha 2ndry structures differ |
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diagnosis
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detect antibodies and amplify only (sc)
if amplification occur.. positve also, we can use proteases on samples ( undegraded prions are infective ) |
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types of vCJD
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inherited, sporadic, acquired
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acquired thru
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blood, transplantation, infected instruments
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