Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
What is psychoneuroimmunology?
|
Psychoneuroimmunology is the study of the relationship between immunity, the endocrine system, and the central and peripheral nervous systems
|
|
|
what is Supersystem dysregulation
|
there is a connection btw the nervous system, immune system, and endocrine system,
when this connection is disrupted, health, function and well-being suffer (fatigue, sleep disturbance, impaired physical and mental function, and depression) |
|
|
4. How does stress affect the immune system?
|
stress leads to the release of cytokines that can affect the HPA axis and lead to widespread effects on the body (TH1 and TH2 release is modified)
|
|
|
what is diathesis?
|
the vulnerability of an individual experiencing stress to a pathological consequence. Two such factors are an individual’s psychological status and social support.
|
|
|
what role do cytokines play in allergy?
|
Dominant Th2 response
Overproduction of histamine IgE production leads to.... Asthma, seasonal and perennial allergic rhinitis, eczema and IgE-mediated food allergy |
|
|
what role do cytokines play in autoimmunity?
|
Dominant Th1 response
Excess IL-12 and TNF- production leads to.... Rheumatoid arthritis, multiple sclerosis, type 1 diabetes mellitus, and autoimmune thyroid disease |
|
|
what role do cytokines play in depression?
|
Dominant pro-inflammatory
cytokine production leads to.. depression |
|
|
remember that Cells of the gut include immune cells (T cells, B cells, mast cells,
neutrophils, macrophages, NK cells, and dendritic cells) and non-immune cells (enterocytes, M cells, goblet cells, enteroendocrine cells, etc). and all of them can be controlled by.... |
The Enteric NS
|
|
|
what is Indoleamine 2,3-dioxygenase (IDO)?
role? what 2 substances does it effect, and what does this lead to? |
An immunosuppressive enzyme
Rate-limiting enzyme of tryptophan catabolism when Trp is depleted: arrests T cells, induces T cell apoptosis, induces Tregs also leads to increased Kyn which generates tolerogenic DCs, suppresses T cell responses |
|
|
in addition to cytokines, what role does IDO play?
|
affects serotonin and melatonin
can lead to depression, SZ, etc these ppl will have higher IDO |
|
|
psychoneuroimmunology is the study of the relationship btw what?
*TEST |
Immune, endocrine, and nervous system
|
|
|
dude suffers from RA and he has just started med school. He is preparing for his first test in anatomy, he visits your office complaining of a marked increase in RA symptoms, what is responsible for this?
*TEST |
Marked increase in Th1 response
|
