Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
Which class of drugs is most frequently used to manage anxiety conditions chronically?
**EXAM** |
Chronic anxiety --> **SSRIs, antidepressants
|
|
|
Which class of drugs is used to treat ACUTE anxiety?
|
BDZs
|
|
|
Which of the BZDs produce no active metabolites?
**EXAM** |
-Temazepam
-Estazolam (bitter aftertaste!) -Lorazepam -Oxazepam **Best used in elderly patients with liver problems** |
|
|
You are seeing an elderly patient for recent anxiety issues. You also not that she has some liver dysfunction. In order to treat her anxiety you decide to prescribe a BDZ.
Which 4 should you consider? **EXAM** |
-Temazepam
-Estazolam (bitter aftertaste!) -Lorazepam -Oxazepam **Best used in elderly patients with liver problems** **NO ACTIVE METABOLITES** |
|
|
This is a non-benzodiazepine anxiolytic
-appears to reduce anxiety by acting as a partial 5HT1A agonist but exact mechanism not clear -Slow onset of activity (weeks) – no good for acute anxiety attacks - Less sedation and lacks anticonvulsant activity, no muscle relaxation - Little or no potential for abuse |
Buspirone
|
|
|
Can you use Buspirone to combat Withdrawal symptoms of a BDZ?
** KNOW, ON EXAM**, |
not effective in blocking WDS of BDZ—NO CROSS DEPENDENCE!
-barbs, or other sedative-hypnotics |
|
|
- Slow onset makes Buspirone unsuitable for acute anxiety attacks; but it is a good alternative for GAD especially with patients with a history of ________
|
Substance Abuse
**Buspirone does not potentiate the effects of alcohol!!!** |
|
|
Name 2 drugs useful in treating OCD
|
***Clomipramine (Anafranil) is a tricyclic antidepressant used in the treatment of OCD
◦ 5HT & NE reuptake blocker ***Fluvoxamine (Luvox) an SSRI used exclusively for OCD |
|
|
What class of drugs is useful in treating alcohol withdrawal?
|
BZDs are used in the treatment of alcohol withdrawal – diazepam, chlordiazepoxide, lorazepam
• In part because these are CROSS-DEPENDENT** - can sub one for the other, no withdrawal…and also using a cross-Rx that has a LONG half life! (recall—the longer than half life, less severe the withdrawal syndrome*) |
|
|
What class of drugs is useful for treating performance anxiety?
|
beta-blockers
|
|
|
Excluding IV midazolam, which BZD has shortest duration of effect?
**EXAM** |
triazolam
|
|
|
Which drug is effective in managing CHRONIC generalized anxiety disorder?
|
Buspirone
|
|
|
Name 2 things that are CYP3A4 inhibitors and can increase BZD levels causing overdose
|
SSRIs, grapefruit juice
**inhibit CYP3A4 and increase BZD levels** (Remember, treat BZD OD w/ flumazenil) |
|
|
Name 2 things that DECREASE effects of BZD
|
smoking and caffeine
|
|
|
Name 2 things that ENHANCE effects of BZDs
|
CNS Depressants and Alcohol
(patients having Alcohol withdrawal can be treated with BZD because of CROSS DEPENDENCE) |
