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20 Cards in this Set
- Front
- Back
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what are the 4 principles of behavioral theory of addiction
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Positive reinforcing effects
Adverse effects Discriminate substance of abuse from other substances Substance seeking behavior is associated with cues that become connected with the experience |
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what makes up brain reward circuitry
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LC, VTA, NA
Locus ceruleus- largest group of adrenergic neurons Catecholamine (particularly dopamine) Ventral tegmental area are particularly important Nucleus accumbens |
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Dependence is defined as
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3 sx in 12 mo
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: inapp. Sexual or aggressive behavior, mood lability, impaired judgment & one or more of the following
Slurred speech Incoordination Unsteady gait Nystagmus Impairment in attention or memory Stupor or coma this is Intoxication or Withdrawal? of what? |
ETOH
intoxication |
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what 3 drugs can kill you in withdrawal
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booze benzos barbs
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2 or more of the following occurring a several hours or few days
Autonomic hyperactivity (sweating or pulse rate >100) Hand tremor Insomnia Nausea or vomiting Hallucinations (a/v/t) Psychomotor agitation Anxiety Grand mal seizure this is Intoxication or Withdrawal? of what? |
ETOH
withdrawal |
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tx for alcohol withdrawal
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Benzos
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etoh dependence tx
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Disulfiram (Antabuse): inhibits aldehyde dehydrogenase causing a build-up of aldehyde causing flushing, sweating, nausea, and tachycardia
Naltrexone: opioid receptor blocker reduced craving and reward response Acamprosate (Campral): affects glutamate and GABA neurotransmitter systems |
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why do many meth addicts go through depression when getting clean
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Methamphetamine appears to have a neurotoxic effect, damaging brain cells that contain dopamine and serotonin
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Increased wakefulness
Increased physical activity Decreased appetite Increased respiration Hyperthermia Euphoria. signs of pts on... |
Methamphetamine
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pupillary dilation=
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meth intox
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Tachy/bradycardia
Pupillary dilation hi BP Perspiration/chills nausea/vomiting Wt. loss Psychomotor agitation/retardation Muscular weakness, respiratory depression, chest pain Confusion, seizures, dyskinesias, dystonias, coma intox or withdrawal? what drug |
intox
meth |
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Fatigue
Vivid, unpleasant dreams Insomnia/hypersomnia Increased appetite Psychomotor agitation or retardation Peak within 2-4 days and resolve in a week w/ most serious symptom being depression. intox or withdrawal? what drug |
withdrawal
meth |
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tx for ppl getting off meth
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Buproprion (Wellbutrin) produces feelings of well-being as they cope with the dysphoria
inhibit DA/NE reuptake |
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how do you get euphoria w/ cocaine
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strong DA reuptake inhibition in brain
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CT scan of brain, huge intaparenchymal bleed=
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cocaine
vasoconstriction |
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euphoria, apathy, dysphoria, psy. Agitation/retardation
Pupillary constriction and one or more of the following Drowsiness or coma Slurred speech Impairment in attention or memory intox or withdrawal? what drug? |
intox
opioid |
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: cessation of use and three or more
Dysphoric mood Nausea/vomiting Muscle aches Lacrimation/rhinorrhea Pupillary dilation, piloerection, sweating Diarrhea Yawning Fever insomnia intox or withdrawal? what drug? |
withdrawal
opiod |
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*******
Alcohol and all drugs of this class (sedative/hypnotic/anxiolytic) are cross tolerant and their effects are additive. |
this is a test question
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major sign of barbituate withdrawal?
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seizures
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