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6 Cards in this Set

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True or False:

Blunt force injuries to the brain contributes to most to the TBI-related morbidity and mortality via the generation of shear and tensile strains within the brain and its vasculature.
FALSE!

RAPID ACCELERATION/DECELERATION of the brain contribute to most TBI related morbidity and mortality!
What does the Glasgow Coma Scale (GCS) grade? Along what categories?
GCS grades the TBI severity. It is a 15 point scale evaluating best eye, verbal and motor responses.

13-15= Mild TBI, including concussion, usually good prognosis
9-12 = Moderate TBI
8 or less = Severe TBI
Mild TBI or concussions can be characterized by:
- Alteration of mental status with or without the loss of consciousness
- Impairment of memory and attention
- Headaches-can persist for days to weeks
- Unsteadiness and dizziness
- Nausea and vomiting
- Sleep disturbances-also can persist for days or weeks.

Which is useful for discerning a veteran with traumatic brain injury versus a veteran with PTSD?
Headaches.

Individuals with PTSD do not usually complain of headaches but those with TBI nearly always complain of headaches!
TBIs can be classified generally into focal and diffuse/generalized. Differentiate between the two.
Focal
-Arises due to acceleration/deceleration induced contact between the brain and the inner table of the skull
-Defined and localizable pathologic process which impacts the injured region in a relatively homogenous fashion
-e.g. Contusion as well as Subdural and Epidural Hematoma formation


Diffuse/Generalized
-Arises from rapid acceleration-deceleration of the head → shear and tensile loading within the brain
-Cells and/or processes within the area of injury are not equally affected
-The area of injury or injuries may be poorly localized or spread over large regions of the brain
-e.g. Diffuse axonal injury, Neuroexcitation
Inflammation typically follows contusion and diffuse necrosis. Which of the following is normally NOT seen for inflammation?

A. IL-1 beta
B. TNF alpha
C. IL-6
D. IL-4
D. IL-4
[ Epidural / Subdural ] hematoma is bleeding between the dura mater and the skull; [ Epidural / Subdural ] hematoma is bleeding between the arachnoid mater and dura mater.