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28 Cards in this Set
- Front
- Back
Salicylates
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- antiinflamm, prophylactic for MI and colon cancer
– covalently! blocks COX1&2, – does all tox – large doses can cause salicylism (tinnitus, dizziness, confusion, and nausea) – moderate dose compensated resp alkalosis, larger uncompensated alkalosis, and v. large doses acidosis, coma, and death – can also cause Reyes syndrome (encephalitis) in varicella and flu |
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Ibuprofen
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- inhibits COX 1,2
– as potent as aspirin in antiinflamm, but less GI tox |
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Acetaminophen
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- antipyretic and analgesic, weakly anti-inflammatory, so not truly an NSAID
– less GI irritation and no Reyes syndrome – may inhibit alternatively spliced forms of COX1&2 in CNS – liver tox can occur w/ doses 2-3x recom¬mended dose - Nephropathy also been associated w/ chronic use |
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Naproxen
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a widely used, typical non-selective NSAID
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Piroxicam
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- NSAID
- long ½ life, so can be used on a 1x daily regimen – but mainly non-selective |
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Etodolac
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- newer drug w/ longer dosing interval (1 x daily)
- relatively mild GI tox - some selectivity for COX 2 |
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Nabumetone
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– partially COX2 selective NSAID
– lower GI tox |
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Misoprostol
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– PGE analog to reduce GI SE’s of chronic tx
– can induce abortions |
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celecoxib
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- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function - may increase risk of adverse CV events |
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rofecoxib
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- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function - may increase risk of adverse CV events |
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valdecoxib
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- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function - may increase risk of adverse CV events |
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zileuton
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- blocks 5-lipoxygenase
- decreases LT's and used for asthma |
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zafirlukast
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- blocks LT4
- so decreases LT's and used for asthma |
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aurothiomaleate
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- Gold Salt, Parenterally administered
- DEMARD w/ unknown mechanism – Dermatitis, BM impairment, renal tox are SE’s |
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aurothioglucose
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- Gold Salt, Parenterally administered
- DEMARD w/ unknown mechanism – Dermatitis, BM impairment, renal tox are SE’s |
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Hydroxychloroquine
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antimalarial thats a DMARD
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Chloroquine
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antimalarial thats a DMARD
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Etanercept
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- DMARD thats a ‘decoy’ TNF receptor
- SE’s are re-emergence of latent TB, and autoimmune syndromes |
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Infliximab
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- DMARD thats an anti-TNF monoclonal Ab’s
- SE’s are re-emergence of latent TB, and autoimmune syndromes |
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Colchicine
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- for gout
- an anti-microtubule agent that blocks LT migration and phago, elieving the attack – SE’s are GI tox, esp diarrhea |
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Allopurinol
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- for gout
- inhibits xanthine oxidase the key enzyme in uric acid production – it reduces urate load and prevents attacks – SE’s are GI tox |
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Probenecid
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- Uricosuric Agents for gout
- weak acids that reduce net resorbtion of urate from urine, reducing urate load – can cause GI irritation |
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Sulfinpyrazone
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- Uricosuric Agents for gout
- weak acids that reduce net resorbtion of urate from urine, reducing urate load – can cause GI irritation |
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dimenhydrinate
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older H1 antagonist
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diphenhydramine
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older H1 antagonist
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fexofenadine
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newer H1 antagonist
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loratadine
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newer H1 antagonist
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Cetirizine
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newer H1 antagonist
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