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28 Cards in this Set

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  • Back
Salicylates
- antiinflamm, prophylactic for MI and colon cancer
– covalently! blocks COX1&2,
– does all tox
– large doses can cause salicylism (tinnitus, dizziness, confusion, and nausea)
– moderate dose compensated resp alkalosis, larger uncompensated alkalosis, and v. large doses acidosis, coma, and death
– can also cause Reyes syndrome (encephalitis) in varicella and flu
Ibuprofen
- inhibits COX 1,2
– as potent as aspirin in antiinflamm, but less GI tox
Acetaminophen
- antipyretic and analgesic, weakly anti-inflammatory, so not truly an NSAID
– less GI irritation and no Reyes syndrome
– may inhibit alternatively spliced forms of COX1&2 in CNS
– liver tox can occur w/ doses 2-3x recom¬mended dose
- Nephropathy also been associated w/ chronic use
Naproxen
a widely used, typical non-selective NSAID
Piroxicam
- NSAID
- long ½ life, so can be used on a 1x daily regimen
– but mainly non-selective
Etodolac
- newer drug w/ longer dosing interval (1 x daily)
- relatively mild GI tox
- some selectivity for COX 2
Nabumetone
– partially COX2 selective NSAID
– lower GI tox
Misoprostol
– PGE analog to reduce GI SE’s of chronic tx
– can induce abortions
celecoxib
- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function
- may increase risk of adverse CV events
rofecoxib
- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function
- may increase risk of adverse CV events
valdecoxib
- COX 2 I
- substantial reduction in GI tox and don’t inhibit platelet function
- may increase risk of adverse CV events
zileuton
- blocks 5-lipoxygenase
- decreases LT's and used for asthma
zafirlukast
- blocks LT4
- so decreases LT's and used for asthma
aurothiomaleate
- Gold Salt, Parenterally administered
- DEMARD w/ unknown mechanism
– Dermatitis, BM impairment, renal tox are SE’s
aurothioglucose
- Gold Salt, Parenterally administered
- DEMARD w/ unknown mechanism
– Dermatitis, BM impairment, renal tox are SE’s
Hydroxychloroquine
antimalarial thats a DMARD
Chloroquine
antimalarial thats a DMARD
Etanercept
- DMARD thats a ‘decoy’ TNF receptor
- SE’s are re-emergence of latent TB, and autoimmune syndromes
Infliximab
- DMARD thats an anti-TNF monoclonal Ab’s
- SE’s are re-emergence of latent TB, and autoimmune syndromes
Colchicine
- for gout
- an anti-microtubule agent that blocks LT migration and phago, elieving the attack
– SE’s are GI tox, esp diarrhea
Allopurinol
- for gout
- inhibits xanthine oxidase the key enzyme in uric acid production
– it reduces urate load and prevents attacks
– SE’s are GI tox
Probenecid
- Uricosuric Agents for gout
- weak acids that reduce net resorbtion of urate from urine, reducing urate load
– can cause GI irritation
Sulfinpyrazone
- Uricosuric Agents for gout
- weak acids that reduce net resorbtion of urate from urine, reducing urate load
– can cause GI irritation
dimenhydrinate
older H1 antagonist
diphenhydramine
older H1 antagonist
fexofenadine
newer H1 antagonist
loratadine
newer H1 antagonist
Cetirizine
newer H1 antagonist