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17 Cards in this Set
- Front
- Back
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What anxiety disorders may be treated w/ low doses of anxiolytics?
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Panic disorder
generalized anxiety disorder |
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Amabarbital, phenobarbital, & thiopental are examples of what drug class?
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barbiturates
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Diazepam, midazolam, lorazepam are examples of what drug class?
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benzodiazepines
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What is the MOA of diazepam?
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BZD:
bind distinct allosteric site --> potentiates GABA binding the A receptor |
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What is the MOA of thiopental?
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barbituate:
bind distinct allosteric site --> potentiates GABA binding the A receptor At HIGH dose: GABA independent agonist |
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BZD's are safer than barbiturates, but what are some potential overdose problems?
How can you treat BZD toxicity? |
1. Can cause respiratory depression
BZD + ETOH can cause respiratory FAILURE 2. flumazenil: antagonist of BZD binding site of GABA-A receptor |
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What BZD is used for anxiety disorder and as a skeletal muscle relaxant?
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Diazepam
(long-acting BZD) |
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What BZD is used for insomnia (trouble STAYING asleep)?
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Flurazepam (long-acting BZD)
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What BZD is used as a pre/peri-operative sedative?
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midazolam (short/intermediate-acting)
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What BZD is used for insomnia (trouble FALLING asleep)?
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Triazolam (short/intermediate-acting)
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What 2 BZD's are used to treat panic attacks and general anxiety disorder?
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Alprazolam
lorazepam (short/intermediate-acting) |
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For BZD's, tolerance develops to what effects?
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sedative and hypnotic effects
NOT to anxiolytic effects BZD's confer cross-tolerance to barbiturates and ETOH |
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Which barbiturate is most useful for inducing anesthesia?
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thiopental (ultra-short acting)
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Which drug class is described by the following (BZD'S or B's):
active metabolites no CYP induction other drugs alter IT'S clearance (v. altering other drugs clearance) |
BZD's
barbiturates are the opposite both are metabolized hepatically |
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What drug is a 5HT-1A/5HT-2 partial agonist that is an anxiolytic (only) and does not interact w/ alcohol or cause dependence?
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Buspirone
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What drug may be used to treat performance anxiety when autonomic symptoms are severe enough to interfere w/ tasks?
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Propanolol
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What drug is an MT-1/2 receptor agonist?
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ramelteon
used for insomnia (help falling asleep) |
