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8 Cards in this Set
- Front
- Back
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Acetylcholine (ACh)
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-Projects especially from basal nuclear complex to cerebral cortex
-Cholinergic neurons also located in striatal interneurons, motor nuclei, preganglionic neurons -Highest concentrations found in projection areas such as cortex, striatum, thalamus -Diseases: HD, AD |
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Dopamine (DA)
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-Nigrostriatal: Especially from substantia nigra pars compacta to striatum
-Mesolimbic: Also from VTA to limbic structures -Tuberoinfundibular: Also from hypothalamus to pituitary -Mesocortical: VTA to prefrontal cortex -Disease: PD, SZ, Cocaine/Amphetamine abuse, prolactin dysregulation |
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Norepinephrine (NE)
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-Locus ceruleus to forebrain
-Depression, food intake, body temp regulation |
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Serotonin
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-Median raphe to forebrain, cerebellum, cord
-Disease: depression, pain, circadian rhythms/sleep-wake cycles, myoclonus, migraine |
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GABA
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-Primary inhibitory neurotransmitter in the brain
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Glycine
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-Primary inhibitory neurotransmitter in the spinal cord
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Glutamate, aspartate
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-Primary excitatory neurotransmitters in the brain
-These are excitatory amino acids -glutamate responsible for 75% of excitatory transmissions in brain -highest concentration of synapses in dentate gyrus, cerebral cortex, and striatum |
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Neuropeptides
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Colocalized with conventional neurotransmitters (like neuromodulators)
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