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18 Cards in this Set
- Front
- Back
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Where is CSF located?
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Ventricles
Subarachnoid space Virchow-Robbins space |
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What are some function of CSF?
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1. shock absorber
2. remove extracellular fluid analogous to lymph drainage. 3. transport hormones released by hypothalamus. |
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What are the 2 places that make CSF?
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1. Choroid plexus: 80%
2. BBB: 20% |
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Name some molecules that cross BBB.
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Nicotine, ethanol, diazepam, heroin, chloramphenicol.
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1. How does L-glucose cross BBB?
2. Why is phenytoin not able to cross BBB? |
1. glucose tranporter. (D-glucose does not cross BBB).
2. multidrug-resistant transport |
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Name some places in the brain that do not have BBB.
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Circumventricular organs: Pineal gland
subcommisural organ subforrical organ neurohypophysis area postrema organum vasculasum of lamina terminalis * involved in body fluid homeostasis and release of hormones into the blood stream. |
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Is the rate of CSF absorption constant?
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No. It is pressure dependent(ICP).
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The higher the ICP(intracranial pressure), the ____ (faster/slower) the CSF is absorbed into the sagital sinus.
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faster
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Increased production of CSF will lead to ____ (increase/decrease) in ICP.
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increase
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Decreased absorption of CSF will lead to ____ (increase/decrease) in ICP.
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increase
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What ion concentrations are lower in CSF than plasma?
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K+, Ca2+, glucose, amino acids, protein
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Which of the following ions has higher concentration than in the plasma?
A. K+ B. Na+ C. Ca2+ D. Cl- |
D.
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What are some functions of extracellular fluid in the brain?
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1. transport materials between cells: neuron-neuron, neuron-glia, glia-capillary.
2. provide homeostatic environment for neural activity. |
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Extracellular fluid in CNS is regulated by which 2 types of cells?
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1. astrocytes (neuronal soma, axons, dendrites).
2. oligodendrocytes (axons). |
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Which type of cells produce extracellular matrix?
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capillary endothelial cells
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What is the function of extracellular fluid that is regulated by astrocytes near axons?
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absorb K+ (buffering system for action potentials).
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What is the function of extracellular fluid that is regulated by astrocytes at neuronal synapse?
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Reuptake of neurotransmitters: Na+/glutamate contransport into astrocyte, glutamate modified to glutamine by glutamate synthetase, glutamine transported to axon terminal.
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What is the function of extracellular fluid that is regulated by astrocytes near capillaries?
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relaxation of blood vessels: glutamate stimulate Ca2+, acitvate IP3 which then activate COXI. Prostaglandins are produced to cause vasodilation.
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