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13 Cards in this Set

  • Front
  • Back
Levo-dopa
1) What is it used for?
2) Does it cross the BBB?
3) What enzyme converts it?
4) Short or long half-life?
It is used to enhance dopaminergic activity in the treatment of Parkinsonism.
It can cross the BBB and is converted by dopa decarboxylase to dopamine. It has a short half-life (50 minutes)
Carbidopa
1) What is it used for?
2) Where does it work?
3) MOA?
4) Cross the BBB?
5) Side effects?
Carbidopa is used to increase dopaminergic activity to treat Parkinsonism. It is a peripheral dopa-decarboxylase inhibitor; it doesn't cross the BBB. Even though it works in the periphery, it increases the amount of L-dopa that is available to the brain and it decreases peripheral side effects. Side effects are dyskinesia, "on-off phenomenon"
Bromocriptine
1) Indications
2) Benefits
Bromocriptine
*a Dopamine Agonist; can be used for Parkinson's
*pts can use less levodopa (so there are less motor complications and "on-off phenomenom"
*only for pts under 70 yo
Amantadine
1) Indications
2) MOA
Amantadine
*used for Parkinson's
*may release dopamine and Norepi from storage, and inhibit dopamine and NE reuptake
Selegiline
1) Indications
2) MOA
Selegiline
* used for Parkinson's, depression
* prevents dopamine breakdown by selectively inhibiting MAO-B
* SE: can cause insomnia and enhance the side effects of L-dopa
Entacapone
1) Indications
2) MOA
Entacapone
* Parkinson's
* Reversible COMT inhibitor in the periphery, so there is more levodopa available
* it decreases the "off" time in the "on-off" symptom
Benztropine
1) Indication
2) MOA
Benztropine
* Parkinson's to control tremors and rigidity
* It competitively inhibits ACh from binding to muscarinic receptors in the CNS
Amitriptyline
1) Indications
2) MOA
Amitriptyline
* Depression; Improve sleep patterns; Nerve pain
* a tricyclic antidepressant; it decreases reuptake of NE and serotonin
Mnemonic for Parkinson's drugs
BALSA
(Bromocriptine, Amatadine, L-dopa/carbidopa, Selegiline, Antimuscarinic (benztropine))
Naproxen
1) Class
2) Indications
3) MOA
Naproxen
* intermediate NSAID, analgesic, antipyretic
* use for rheumatic diseases, strains, sprains, dysmenorrha, fever
* reversible non-selective COX inhibitor (COX-1 and COX-2) so that arachadonic acid isn't converted to PGs and thromboxane
Acetaminophen
1) Indications
2) MOA
Acetaminophen
* mild to moderate pain, fever; good for children because they can't take aspirin due to risk of Reye's syndrome
* reversibly inhibits COX but not an anti-inflammatory and no anti-platelet effect
Cyclobenzaprine (Flexaril)
1) Class
2) Indications
3) MOA
Cyclobenzaprine
* Skeletal Muscle Relaxant
* for muscle spasms
* MOA unsure
Omeprazole
1) Class
2) Indications
3) MOA
Omeprazole
* Proton pump inhibitor
* Peptic ulcer disease, GERD, Zollinger-Ellison syndrome
* It inhibits the gastric parietal cell proton pump (a H/K/ATPase)