Neuro Drugs

Front 1

Levo-dopa
1) What is it used for?
2) Does it cross the BBB?
3) What enzyme converts it?
4) Short or long half-life?

Back 1

It is used to enhance dopaminergic activity in the treatment of Parkinsonism.
It can cross the BBB and is converted by dopa decarboxylase to dopamine. It has a short half-life (50 minutes)

Front 2

Carbidopa
1) What is it used for?
2) Where does it work?
3) MOA?
4) Cross the BBB?
5) Side effects?

Back 2

Carbidopa is used to increase dopaminergic activity to treat Parkinsonism. It is a peripheral dopa-decarboxylase inhibitor; it doesn't cross the BBB. Even though it works in the periphery, it increases the amount of L-dopa that is available to the brain and it decreases peripheral side effects. Side effects are dyskinesia, "on-off phenomenon"

Front 3

Bromocriptine
1) Indications
2) Benefits

Back 3

Bromocriptine
*a Dopamine Agonist; can be used for Parkinson's
*pts can use less levodopa (so there are less motor complications and "on-off phenomenom"
*only for pts under 70 yo

Front 4

Amantadine
1) Indications
2) MOA

Back 4

Amantadine
*used for Parkinson's
*may release dopamine and Norepi from storage, and inhibit dopamine and NE reuptake

Front 5

Selegiline
1) Indications
2) MOA

Back 5

Selegiline
* used for Parkinson's, depression
* prevents dopamine breakdown by selectively inhibiting MAO-B
* SE: can cause insomnia and enhance the side effects of L-dopa

Front 6

Entacapone
1) Indications
2) MOA

Back 6

Entacapone
* Parkinson's
* Reversible COMT inhibitor in the periphery, so there is more levodopa available
* it decreases the "off" time in the "on-off" symptom

Front 7

Benztropine
1) Indication
2) MOA

Back 7

Benztropine
* Parkinson's to control tremors and rigidity
* It competitively inhibits ACh from binding to muscarinic receptors in the CNS

Front 8

Amitriptyline
1) Indications
2) MOA

Back 8

Amitriptyline
* Depression; Improve sleep patterns; Nerve pain
* a tricyclic antidepressant; it decreases reuptake of NE and serotonin

Front 9

Mnemonic for Parkinson's drugs

Back 9

BALSA
(Bromocriptine, Amatadine, L-dopa/carbidopa, Selegiline, Antimuscarinic (benztropine))

Front 10

Naproxen
1) Class
2) Indications
3) MOA

Back 10

Naproxen
* intermediate NSAID, analgesic, antipyretic
* use for rheumatic diseases, strains, sprains, dysmenorrha, fever
* reversible non-selective COX inhibitor (COX-1 and COX-2) so that arachadonic acid isn't converted to PGs and thromboxane

Front 11

Acetaminophen
1) Indications
2) MOA

Back 11

Acetaminophen
* mild to moderate pain, fever; good for children because they can't take aspirin due to risk of Reye's syndrome
* reversibly inhibits COX but not an anti-inflammatory and no anti-platelet effect

Front 12

Cyclobenzaprine (Flexaril)
1) Class
2) Indications
3) MOA

Back 12

Cyclobenzaprine
* Skeletal Muscle Relaxant
* for muscle spasms
* MOA unsure

Front 13

Omeprazole
1) Class
2) Indications
3) MOA

Back 13

Omeprazole
* Proton pump inhibitor
* Peptic ulcer disease, GERD, Zollinger-Ellison syndrome
* It inhibits the gastric parietal cell proton pump (a H/K/ATPase)