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27 Cards in this Set

  • Front
  • Back

Teratogens


Agenesis

The failure of an organ to develop

Dysgenesis

Abnormal development of an organ

Teratogen diseases

Rubella, influenza, mumps, sexually transmitted diseases, drugs,

Teratogens


Environment

Environmental toxins such as mercury, carbon monoxide, lead, and polychlorinated biphenyls and radiation

Teratogen impact

Particular period of rapid brain growth, the genetic makeup of he child/mother, the quality of the intrauterine environment and the dosage of experience, spontaneous abortions,

Polymicrogyria

Distribution of the structure of developing

Porencephaly

Brain formation in which cystic lesions are on the surface of the brain

Heavy metals as neuron toxins

-Lead most widespread neurotoxins in the world due to its presence in gasoline, paint, and industrial plants.


- can be exposed through both older and substandard homes painted with lead- based paint, contaminated soil, and water


- major source for pregnant industrial/ work setting.

Birth accidents: anoxia

-Complete cessation of oxygen supply to the brain.


- occurs with stroke, severe traumas to the brain such as a gunshot wound.

Birth accidents : medication

Introduced using labor and deliveries

Trauma

Mechanical injury to the skull and brain caused by trauma damage during delivery

Brain plasticity

-The enduring changes in neural activity that accompany learning, or the recorder of behavioral functioning after brain injury or disease.


- greatest during developmental periods when synaptic density is highest

Kennard principle

Suggests that the immature brain is more plastic than the mature brain

Brain differences with age and injury

Age: children w/ early focal brain injury have milder and less extensive cognitive and emotional impairments then adults with comparable lesions


-Earlier lesions can have effect on developing functions.


-before age 1 more global and lasting impairment.


- 1-5 neural reorganization and sparing function is possible.


- after age 5 minimal recovery of function.



Language development functions

- young children who experience such injury rarely suffer from aphasia, most w/ early left hemp damage acquire language abilities within the lower end of the average range


- adults w/ similar lesions show high prevalence of aphasic disorders and recovery is less likely

Anencephaly

Failure in development of the two hemispheres. Produces severe neurological deficits and is incompatible w/ life

Hydrocephalus

Ventricles become abnormally enlarged most related to problem with cerebrospinal fluid flow, production, or absorption

Hydranencephaly

Absent to varying degrees

Spinal bifida

By an opening in the spinal cord, consequence of a failure of the prosterior end of the neural tube to close during despairing

Obstructive or noncommunicating HC

-A form of hydrocephalus produced by obstruction within the ventricular system.


-consequence of congenital malformation, rumors, or scaring

Arnold chiari

A condition in which brain tissue extends into the spinal canal, present at birth

HC impact on brain and treatment

-Unchecked HC has a devastating impact on brain development.


-As CSF volume increases, the ventricles progressively enlarge in a posterior to anterior direction w/ corresponding disruption of brain anatomy and function


Treatment- shunt: drains excessive CSF away from the ventricular system into our stomach

Turner's

-Failure to develops secondary sexual characteristics short stature, webbed neck, and cubitus valgus.


-caused by an anomaly in the X chromosome(female).

Williams

Recognizable pattern of dysmorphic facial features, cardiovascular and physical abnormalities, mental retardation, a specific cognitive profile, and a distinct personality

Fetal alcohol system: features

Growth retardation, widely spaced eyes, shortened length of eyelids, elongated midface, flattened nose, thin upper lip.

FAE

Children who are exposed to alcohol in utero but fail to show growth deficits or other abnormalities of FAS may still show functional impairments of FAS.


- may manifest sensory and sensorimotor impairments speech and language delay, cognitive and learning weakness, impulsivity and hyperactivity

Neuropathology

Consequence of alcohol use of mother during pregnancy.


- teratogenic effects of prenatal alcohol exposure to intake (amount, frequency, and drinking patterns(, period of brain development and maternal health poorly understood