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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What kills people from opoids
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resp depression
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how do CNS depressants increase neuronal inhibition
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by increasing Chlorid ion flux throug the ion channel thus enhancing GABAa receptor function
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how do CNS depressants inhibit excitatory neurotransmission
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via NMDA receptor
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Flumoazenil MOA and use
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benzodiazepine antagonist that binds to GABAa receptors for benzo overdose only
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Cocain MOA
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blocks DAT transporter and at high concentraiton block 5HTT and NET
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what to give to help psychostim overdose and what NOT to give?
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Sedate with benzos do NOT give beta-adrenergic antagonists
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Biphasic drug activation measnw hat?
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behavioral activation at low dose and sedation at higher doses
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most important receptor for reinforincg actions of opiods
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u opoid receptor = MOR
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Naloxone MOA
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pure antagonist of all opoid receptors
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what receptor and what pathway does nicotine activate
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Nicotine ach receptor and activates in the dopaminergic brain reward pathway
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Type of receptor that THC activates
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Gprotein CB1, what is its endogenous ligant and receptor class
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anandamide and endocannabinoid
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what to give for overdose of THC
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benzos for anxiety
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none
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LSD MOA
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serotinin agonist, PCP MOA?
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blocks NMDA glutamate
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MDMA MOA
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relesease sert, blocks sert syn and blocks reuptake what to give for ovrdose of MDMA
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benzos
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what is acquired tolerance
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repeates use of drug causes adaptive physio responses whch oppose which oppose the pharm actions what ate teh 3 forms of acquired tolerance
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1. Metabolic (pharm) 2. Fucntional (dynamic) and behavioral (learned ) tolerance
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what is metabolic tolerance
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body eliminates drug fast so a lower molar concenrtraion is available what is fucntional and behavioral tolerance?
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Functiona is neuronal adaptioans that cause reduced response and Behavioral-environental cuse cause a pre-emptive conditionalr esponse that is reflexsive and compensatory=conditionared opponent response
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what is sensitization
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same amount of drugs elicits more itnens stimulatory effectsmos what drugs types does this occur in?
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mostly stimulatns but cna ocure in the stim component of teh bipasic depressant response
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How do CNS depressants cause withdrawl
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by down refulating GABAa receptors what drugs have the worse withdrawo
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fast acting fast elimination
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what other receptror is upregulated in alcohol tolerance
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NMDA receptors and whats causes many of the etoh withdrawl symptoms and whaqt med to you give for withdrawl
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sympathathetic hyperactivity and give nezos
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what drugs to give for opoid withdrawl
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clonidine to reuce alpha2 adrenergic activity abd netgidibe ti king acting opoid
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Disulfram MOA
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aversive acetaldehyde reaction
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Naltrexone MOA
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competitvel blocks the bidnign of opoids to u receptor=opoid antagonist
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what else can naltrexoe be used for
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opoids and alcohol dependence
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Acomprosate MOA
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modulates glutamade hyperactivity to stop alcohol relapse, helps with long term dysphoria and dysfunctional reward
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Topiramate
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anticonvulsant that inhibts AMPA kainate receptors to reduce drining
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Buprenorphine
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is a mu/ u opoir receptoa agonos antagonist MOR, alleviates withdrawl and alleviates craving by partial MOR agaonism
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