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17 Cards in this Set
- Front
- Back
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What class of drugs do the following drugs belong to?
Citalopram Fluoxetine Fluvoxamine Paroxetine Sertraline |
SSRIs
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Name 4 SSRI drugs
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Citalopram
Fluoxetine Fluvoxamine Paroxetine Sertraline |
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What are the indications for SSRIs?
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Major depression
Dysthymia Anxiety disorders (panic disorder, OCD) |
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What is the mechanism of action of SSRIs?
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Highly selective blockade of presynaptic 5-HT uptake
Increase levels of 5-HT in the synapse Little action on ACh and histamine receptors |
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What class do the following drugs belong to:?
Amitriptyline Clomipramine Dothiepin Doxepin Imipramine Nortriptyline Trimipramine |
TCAs
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Name 2 TCA drugs?
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Amitriptyline
Clomipramine |
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What are the indications for TCAs?
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Major depression
Anxiety disorders (OCD, phobias) Nocturnal enuresis Depression associated with schizophrenia |
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What is the mechanism of action of TCAs?
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Block presynaptic NA & 5-HT transporters
Increase levels of NA & 5-HT in synapse Also block mACh, 5-HT, α-adrenoceptor and Histamine receptors |
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What class do the following drugs belong to:
Moclobemide Maosig, Phenelzine Tranylcypromine |
MAOIs
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Name 3 drugs in the MAOI class
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Moclobemide
Maosig Phenelzine Tranylcypromine |
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What are the indications for MAOIs?
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Major depression
Major depression when other antidepressants have not worked (Phenelzine) Atypical depression Phobic anxiety & panic disorder Social phobia (Moclobemide) Anorexia and bulimia nervosa |
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What is the mechanism of action of MAOIs?
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Irreversible, non-selective (phenelzine, tranylcypromine)
Binds covalently to MAO-A & MAO-B Prevents breakdown of NA, 5-HT & DA Increases cytoplasmic pool of monoamines Increases leakage of monoamines into synapse/ extracellular space Reversible, MAO-A selective (moclobemide) Binds reversibly to MAO-A Prevents breakdown of NA & 5-HT Increases cytoplasmic pool of monoamines Increases leakage of monoamines into synapse/ extracellular space |
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What are the indications for atypical antidepressants?
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Major depression
Prevention of relapse of major depression Anxiety disorders (GAD, social phobia) |
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What is an example of an α2-adrenoceptor blocker (atypical antidepressant)?
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Mirtazapine
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What is an example of a SNRI drug (atypical antidepressant)?
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Venlafaxine
Duloxetine |
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What is the mechanism of action of SNRIs
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Block presynaptic NA
AND/OR 5-HT transporters Increase levels of NA & 5-HT in the synapse |
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What does PICOT stand for and how it is used?
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To formulate questions in Evidence Based Practice, use the PICOT format.
PICOT stands for: Population/ Patient Problem: Who is your patient? (Disease or Health status, age, race, sex) Intervention: What do you plan to do for the patient? (Specific tests, therapies, medications) Comparison: What is the alternative to your plan? (ie. No treatment, different type of treatment, etc.) Outcome: What outcome do you seek? (Less symptoms, no symptoms, full health, etc.) Time: What is the time frame? (This element is not always included.) |
