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49 Cards in this Set
- Front
- Back
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Seizure drugs that have Na channel activation as their MOA
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Phenytoin
carbameazepine lamotirigine |
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seizure drugs with increased GaBA action as mech
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phenobarb
BDPs tiagabine vigabatrin levetracetam |
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mixed seizure drugs
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topiramate
valproic acid |
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ethosuximide
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blocks thalamic T-type ca channels
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teratogenic effects of phenytoin
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cleft palate
cardio problems MR fetal hydantoin syndrome |
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increases liver enzyme synthesis
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barbiturates
tx crigler najjar this way |
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longest acting benzo
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diazepam
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nephrotoxic inhaled anesthetic
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methoxyflurane
(meth is neph) |
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depolarizing NM blocker
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succinylcholine
phase I - muscle ctx and no antidotes phase II - repolaraized but blocked. antidote - neostigmine |
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malingnant hyperthermia
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RyR1 gene defect
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out put pathway of cerebellum
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brachium conjunctivum/ superior cerebellar peduncle to the contralateral VL of thalmus
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damage to spinocerebellum (vermis and paravermis)
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postural instability
slurred/slow speech hypotonia pendular knee jerk reflexes |
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anterior cerebellar lobe damage
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ataxia of legs
broad based staggering gait thiamine defieiceny works here |
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damage to lateral cerebellum/cerebrocerebellum
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lack of coordination
delay in initiating movement trouble stopping movement dysmetria intention tremor |
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damage to vestibulocerebellum (vermis and flocculonodular)
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no balance
abnormal eye movements like nystagmus |
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MCC of damage to flocculonodular lobe
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medulloblastoma in childhood
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hallmark of brainstem lesion
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long tract s/s on one side
cranial nerve s/s on other side |
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weber's syndrome
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midbrain infarct d/t occlusion of paramedian branches of PCA
cerebral peduncle lesion: C/L spastic paralysis CNIII palsy: I/L ptosis dilation later stabismus |
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medial medullary syndrome
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occlusion of paramedian branch of anterior spinal artery
u/l infart of medial rostral medulla (ant spinal artery syndrome) C/L spastic hemiparesis c/l tactile and kenesthetic defects tongue toward side of lesion PAIN AND TEMP PRESERVED |
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lateral medullary syndrome (Wallenberg's syndrome)
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occlusion of PICA
c/l pain and temp i/l pain and temp over face harse difficulty swalling loss of gag reflex vertigo nystagmus n/v i/l cerebellar deficits |
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medial inferior pontine syndrome
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occlusion of paramedian branch of basilar
c/l spastic hemiparesis c/l light touch/vibraiton paralysis of gaze to lesion side i/l abducens PAIN AND TEMP PRESERVED |
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lateral inferior pontine syndrome
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AICA
i/l facial nerve u/l deaf and tinnitus nystagmus, vertigo, n/v i/l lim and gait ataxia i/l pain and temp from face c/l pain and temp body i/l horners no paralysis or DWC loss |
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intraventricular hemorrhage
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orginates in germinal matrix which gives rise to neurons and glia during development
screen 30-32 wks gestational age |
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pseudotumor cerebri
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CSF pressure >200 or 250 in obese
HA worse in morning |
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pseudotumor cerebi tumor tx
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weight loss
stop vitamin A, tetracyclines, steroid w/d acetazolamide |
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syringomyelia
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cape loss of sensation
hand weakness, atrophy B/l loss pain and temp a/q arnold chiari malformation |
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right motor cortex or right corticoblubar tract lesion. which side does the uvula deviate?
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toward
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right motor cortex or right corticobulbar lesion. tongue deviates.....
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away from lesion
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dzs that have bell's palsy
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lyme
Sarcoid Herpes Tumors AIDS DM |
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femoral nerve
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hip flexion
knee extension psoas and iliacus pectineus (flex) rectus femoris vastus lateralis vastus intermedius vastus medialis sartoris (flex) |
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obturator nerve
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a hip adductor
adductor magnus adductor longus adductor brevis gracilis (knee flexion) |
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deep peroneal nerve
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peroneus tertis (eversion)
tibialis anterior extensor hallicus longus extensor digitorum longus (dorsiflexors) |
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superficial peroneal nerve
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peroneus longus
peronus brevis |
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superior gluteal nerve
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injured in posterior hip dislocation/ polio
hip abduction and medial rotation tensor fasciae latae gluteus medis gluteus minimus |
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inferior gluteal nerve
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post hip dislocation
hip extension and lateral rotation gluteus maximus |
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sciatic nerve
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hip extension
knee flexion biceps femoris semitendinosus semimembranosus adductor magnus |
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sacral plexus
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lateral rotators of thigh
gemilus superior and inferior prirformis quad femoris |
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tibial nerve
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gastroc
soleus pantaris popliteus flexor hallicus longus flexor digitorum longus tibialis posterior (inversion) |
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wernig hoffman
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floppy baby
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lewy bodies
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demntia
alzheimers parkinsons |
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hirano bodies
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alzheimers
rod like eosinophilic |
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pick bodies
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filamentous
stain with silver |
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filamentous inclusions that stain with PAS and ubiquitin
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lewey bodies
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drugs that cause stevens-johnsons
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seizures, sulfas, cillins, allopurinol
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hepatotoxic antiepileptics
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valproate
carbamezapine |
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Drugs inducing p450
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"BCG PQRS"
barbs carbamezapine griseofulvan Phenytoid Quinidine Rifampin St. John's Wart |
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Drugs inhibiting p450
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"PICK EGS"
Protease inhibitors INH Cimetidine Ketoconazole Erythromycin Grapefruit juice Sulfonamides |
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Trigeminal neuralgia tx
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carbameazepine
onther anticonvulsants |
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vertigo
tinnitus hearing loss |
menetriers
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