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74 Cards in this Set
- Front
- Back
What are the 4 parts of the Pharyngeal Apparatus?
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Arches, Clefts, Pouches and Membranes
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surrounds the developing pharynx and is the source of mesenchymal tissue that will form the head & neck, face, palate & nasal cavity structures.
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Pharyngeal Apparatus
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The pharynx forms _____ to the brain.
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Ventral
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Of the pharyngeal apparatus, what completely regresses in the human?
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Arch and Pouch #5
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Surface ectoderm-lined invaginations
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Clefts
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How many clefts?
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1-4
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How many arches?
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1-4,6
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Form between the pharyngeal arches.
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Clefts
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Arches are bars of what?
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Mesenchyme
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How many pouches?
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1-4
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Endoderm-lined pouches along the lateral walls of the pharyngeal gut.
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Pouches
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Opposite of clefts
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Pouches (INSIDE) of embryo
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Separate the ‘pouches’ from the ‘clefts’
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Membranes
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Do clefts and pouches communicate in humans?
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No
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What makes up the facial prominences?
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One frontonasal prominence, 2 maxillary, 2 mandibular
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What facial prominence is a proliferation of mesenchyme ventral to brain vesicles?
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Frontonasal Prominence
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The maxillary prominences are extensions of which arch?
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1st
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The mandibular prominences are mesenchyme from which arch?
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1st
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When do the two mandibular prominences merge ventrallyto form the lower lip and jaw plus the inferior part of face?
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Week 4
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What type of mesoderm forms the initial shape of the pharyngeal arches?
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Lateral Plate
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Where does mesoderm migrate from into the pharyngeal arches?
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Somitomeres and Somites
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Eye muscle precursors from?
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Somitomeres
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Tongue precursors from?
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Occipital Somites
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What forms most of the skeletal muscle in the head plus parts of the skull?
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Mesoderm
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What two things migrate into the pharangeal arches?
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Neural crest cells and mesoderm
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What form skeletal elements of the head & parts of the PNS?
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Neural crest cells
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Neural crest cells are what in origin?
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Neuroectodermal
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How are the cranial nerves formed?
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Neurons from the brain and central ganglia grow into the arches
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What arch is the trigeminal nerve derived from?
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1st
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What arch is the facial nerve derived from?
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2nd
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What arch is the glossopharyngeal nerve derived from?
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3rd
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What arch is the vagus nerve derived from?
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4th and 6th
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Motor innervation to those muscles originating in the pharyngeal arches is classified as what?
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Special VE
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What is mandibular cartilage?
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Meckel's cartilage
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What does Meckel's cartilage form?
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Incus, malleus and mandible (but cartilage dissapears)
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What type of ossification do the incus and malleus undergo?
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Endochondral
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What type of ossification does the mandible undergo?
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Intramembranous
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What innervates the muscles of mastication and what is it a derivative of?
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Trigeminal (5), 1st Arch
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What is First Arch Syndrome (Treacher Collins)?
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Deficiency of neural crest cells migrating into the arch.
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Mandibulofacial dysostosis
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Treacher Collins Syndrome (1st Arch)
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What is First Arch Syndrome (Pierre Robin Syndrome)?
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Deficiency of neural crest cells migrating into the arch.
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Micrognathia + large, posteriorly placed tongue > airway obstruction; may be ear and palate problems as well.
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Pierre Robin Syndrome
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Reichert’s cartilage
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2nd arch
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What forms the stapes and styloid process? (inner ear)
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2nd arch; Reicherts cartilage
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What forms the thyroid and circoid process?
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4th and 6th
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What innervates Muscles of the soft palate (except tensor veli palatini)
Muscles of the pharynx (except stylopharyngeus)? |
Superior laryngeal branch Vagus (4th and 6th)
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What innervates the Intrinsic muscles of larynx (except cricothyroid)
Striated (upper) muscle of esophagus? |
Recurrent laryngeal branch of Vagus
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What pouch forms the tubotympanic recess? (Auditory tube, tympanic cavity)
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1st
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What pouch forms the palantine tonisls?
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2nd
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What pouch forms the Thymus?
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Ventral 3rd pouch
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What pouch forms the inferior parathyroid glands?
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3rd pouch (dorsal)
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What pouch forms the superior parathyroid glands?
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Dorsal 4th pouch
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What pouch forms the ultimobranchial bodies (parofollicular or C cells of thyroid)?
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Ventral 4th pouch
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What pouch derivative travels the farthest?
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Inferior parathyroids (Dorsal 3rd)
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No thymus or parathyroids plus…
Failure of neural crest migration into arches --> 3rd & 4th pouch failure & hypoplasia of 1st arch. |
DiGeroge Syndrome
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What should happen to the clefts in normal circumstances?
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1st cleft develops into external auditory meatus while 2,3,4 overgrown by the 2nd arch producing cervical sinus which normally disappears
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What cleft produces the external auditory meatus?
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1st cleft
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What would be the consequence of incomplete overgrowth of the 2,3,4 clefts by 2nd arch?
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Lateral cervical or Branchial cyst
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What is the only membrane that persists in adults and what does it persist as?
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1st membrane as tympanic membrane
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What type of envagination is the thyroid?
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endoderm
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Between what arches is the thyroid formed?
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1st and 2nd
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What is the first endocrine gland to appear, around 4th week?
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Thyroid
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What is the site of origin of the thyroid?
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Foramen cecum of tongue
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When the thyroid fails to descend
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Lingual thyroid
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What arches does the tongue involve?
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1-4
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Oral portion of the tongue is derived form where?
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1st arch
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Where is the posterior or pharyngeal part of the tongue formed?
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3rd arch
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Most of the tongue muscles are derived from what that migrate from the occipital myotomes with the hypoglossal nerve.?
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myoblasts
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What is the site of origin of the throoid?
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Foramen cecum in the tongue
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What connects thyroid to tongue during development?
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Thyroglossal duct
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What is the first endocrine gland to appear at 24 days?
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Thyroid
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Where do the tongue muscle originate?
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myotomes of occipital somites NOT mesenchyme of the arches
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The upward evagination from the roof of the pharynx forms what part of the pituitary?
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Glandular portion
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The downward evagination toward the pharynx forms what portion of the pituitary?
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Neural region
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