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24 Cards in this Set
- Front
- Back
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Name 3 tight junction proteins of the BBB
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Claudin, JAM, occludin
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Where do you find GLUT-1?
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Endothelial cells and capillaries
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facilitates the transport of glucose across the plasma membranes of mammalian cells
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GLUT-1
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What type of cells line the vessel in the BBB?
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Endothelial
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Are endothelial cells symmetric?
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NO (Abluminal and luminal sides)
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Why can alcohol, cocain and heroin cross the BBB?
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They are lipid soluble
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Most of the transporter protein bulk in the BBB are ________?
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Hydrophobic
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What does MCT1, monocarboxylic acid transporter-1 do?
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Transports ketones and lactate (high in young suckling rat)
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What is the only transporter that is not on both the luminal and abluminal side?
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H20 (Only present on luminal side)
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Where are Pgp concentrated and what do they do?
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Luminal side and pump out drugs
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What type of transporter is Pgp?
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ABC (ATP Binding Cassette)
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What ABC transporter lets organic ions pass from brain to lumen?
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OAT 3
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What is the significance of BCRP?
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Resistance to tumor treating drugs. May try to inhibit with one drug and follow with another
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How do hormones and peptides enter the brain?
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Receptors (endocytosed and exocytosed)
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What is rolling of leukocytes during diapedesis dependent upon?
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Selectins
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What is emigration during diapedesis of leukocytes dependent upon?
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Integrins
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What provokes diapedises?
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Chemokines
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What are 2 methods of opening the BBB?
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Osmotic Shock (Hyperosmolar manitol)
and Receptor mediated (TJ opening) |
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Do the pituitary, pineal glads or choroid plexus have a BBB?
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NO
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What type of cells are in the CSF/Blood barrier?
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EPithelial (NOT endothelial)
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How is CSF produced?
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Na, Cl and HCO3 net transport from blood to ventricle where water will follow
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Reduce hydrocephalus with slowing down the production of the fluid by inhibiting carbonic anhydrase... what drug?
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acetazolamide
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Blocking ATPase activity would also reduce CSF fluid... what drug?
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Ouabain
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What drug block the Na/Cl exchanger in CSF production?
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furosemide
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