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5 Cards in this Set

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How do clots occur in the blood vessel?
Exposed subendothelium:
Followed by platelet adhesion to vessel wall:
Release of ADP, thromboxane, collagen, etc
Formation of thrombus
Collection of fibrin, platelets, erythrocytes
Growth of thrombus
Occluded vessels
what is concern with clots venous vs arterial?
Occlusion results in tissue ischemia

Venous thrombus:
Occlusion occurs
But major concern is emboli
List the anti thrombotics:
Inhibitors of cyclooxygenase

Adenosine diphosphate inhibitors

Phosphodiesterase inhibitors

Glycoprotein IIB/IIIA receptor blockers
what is the one drug that is a cyclooxygenase inhibitor, and what does it do to the platlet?
Irreversible acetylation of platelet cyclooxygenase

Inactivated for life of the platelet
How does asprin work, and what is the story with increasing asa doses and antithrombotic efficacy?
It works by promoting
Irreversible inactivation for life of platelet

There is a lack of dose-response relationship
300 or 1500 mg is no better than 50 or 80 mg

The lower the dose, the fewer the SE's.
300 mg = fewer GI events vs 1200 mg
30 mg = fewer SEs vs 300 mg
Do you ever see MI pts getting 1300mg of asa?