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15 Cards in this Set

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what occurs at these blood levels? .15, .4, .6?
.15= loss of speech control, motor control, mental and physical impairment

.4= threshold of coma

.6= die of resp failure
what is the tx for alcohol intox?
symptomatic tx.
how does ethanol produce its effects?
binds to GABA, NMDA, and alters the fluidity membranes.
what are the promary effects of ethanol on CNS, GI, CV, liver, and endocine?
CNS- affects GABA, NMDA, and membrane fluidity

GI- at low doses it stimulates acid secretion but at high doses it stops it

CV- dec in BP, vasodialation, and hypothermia

liver- increase need for gluconeogenesis

endocine- increased need for NAD so may see hypoglycemia
describe the metabolism of alcohol
ethanol-->acetaldehye-->acetic acid

alcohol DH and aldehyde DH
what is the drug interaction between ethanol and other CNS depressents?
they potentiate the effects of ethanol
what is the drug interaction between ethanol and oral hypoglycemics?
causes potentiation of the hypoglycemic effects
what is the drug interaction between ethanol and anticoags?
leads to dec half life of the anticoags
what is the drug interaction between ethanol and anticonvulsants
dec in the half life of the drug
what is the drug interaction between ethanol and ASA
increased rate of gastric hemorrage
what is the drug interaction between ethanol and antimicrobials?
may see disulfuram like reaction
what are some of the signs of withdrawal from alcohol?

Tx?
seizures, inc BP, inc HR,

chordiazeperoxide/diazepam and phytoin for the seizures.
what are some of the signs of FAS?
low IQ, MR, microcephaly, heart defects, facial defects, limb defects, behavior and learning problems
how does methanol cause poisoning?
methanol is broken down into formic acid and formaldehyde. this causes metabolic acidosis and blindness.
what is the MOA of disulfuram and naltrexone?
disulfuram- blocks aldehyde DH and causes disulfuram like rxn

naltrexone- this is an opioid antagonist and blocks the rewarding effects of alcohol