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10 Cards in this Set
- Front
- Back
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What is Nephrotic syndrome?
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Proteinuria
Oedema Hypoalbuminaemia |
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Causes?
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Glomerular disease
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Causes of glomerular disease?
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Glomerulonephritis
Immune - IgA Congenital - Alport syndrome Metabolic - DM Depostion material - amyloid |
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Complications glomerular disease?
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1. Secondary hyperaldosteronism - as drop in oncotic pressure makes kidney reab Na+ & H20
2. Hypercholesterolaemia - as drop oncotic press makes liver prod chol. and can lead to atherosclerosis 3. Increased coagulation - as loss of protein C+S 4. Increased risk infection - loss of Ig's |
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Causes pre-renal failure (arf)
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Hypovolaemia
RAS Heart fail Sepsis (peripheral VD leads to decreased perforation kidney) Rx NSAIDs + ACEi |
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Causes renal - fenal failure (ARF)
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Tubular necrosis (secondary to septic or toxic agents in kidney)
Glomerular disease Interstitial disease e.g. autoimmune nephritis, infection, drug induced |
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Post renal causes (ARF)
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Stones
Tumout BPH Prostat Ca |
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ARF commonly present with metabolic acidosis. T/F
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True
Failure of excretion of H+ May also have Hyperkalaemia secondary to tissue breakdown (e.g. tubulo necrosis), haemolysis and metabolic acidosis May also get hypocalcaemia - failure activate Vit D |
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What is Acute tubular necrosis?
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Necrosis of kidney cells due to - isch, toxins, drugs, infection
Uusually due to acute renal failure if prolonged |
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CI acute renal fail?
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NSAIDs
ACEi |
