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9 Cards in this Set
- Front
- Back
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How many untreated mothers infected with primary or secondary syphilis will transmit the infection to their unborn child?
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70%
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1. According to the CDC, when should all pregnant women be screened for syphilis? 2. When should women at "increased risk" be screened? |
1. The first prenatal visit, whenever that is 2. The beginning of the third trimester and again at delivery. |
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Which neonates should be screened for congenital syphilis?
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All neonates born to a mother with both reactive non-treponemal tests (RPR, VDRL) AND confirming treponemal tests (TP-PA, FTA-ABS, EIA, CIA)
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1. Name the test that should be used to evaluate newborns at risk for congenital syphilis. 2. Which of any 3 tests should NOT be requested? |
1. Quantitative non-treponemal serological test on the neonate's serum (e.g., VDRL, RPR) 2. Avoid requesting: a. Tests involving cord blood b. Treponemal serologies (hard to interpret) b. IgM: not at all reliable |
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What is the most common presentation of an infant born with congenital syphilis?
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60% are completely asymptomatic.
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Name 7 physical findings to be sought out with every newborn suspected of infection with congenital syphilis.
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1. Non-immune hydrops (i.e., no ABO or Rh isoimmunization involved.) 2. Jaundice 3. Hepatosplenomegaly 4. Rhinitis that is thick, copious ("snuffles") 5. Skin rash 6. Osteitis 7. Lack of limb motion because of pain. |
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1. How should pregnant women found to have syphilis be treated? 2. If the patient is allergic to the top choice medication, what should the OB do? |
1. Parenteral PCN G: the only one known to work in this situation; accept no substitutes! 2. Refer the mother for desensitization, THEN get her the PCN G. |
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True or false: while maternal nontreponemal IgG antibodies can cross the placenta, maternal treponemal antibodies can't.
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False. Both groups of antibodies cross the placenta easily. Because of this, serologic diagnosis of congenital syphilis is complicated!
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Name two reasons that tests involving cord blood are useless in the evaluation of newborns suspected of infection with congenital syphilis.
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1. Maternal blood contamination can produce false positives. 2. Contamination of the sample with Wharton's jelly from the cord can produce false negatives. |
