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13 Cards in this Set
- Front
- Back
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Neisseria Characteristics
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gram negative
aerobic diplococci CANOPHILIC (need CO2) |
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Neisseria gonorrhoeae
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gram (-) diplococci
microaerophilic |
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NG disease
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urethritis/cervicitis w/ discharge
males = epididymitis females = PID in 10-20% UTW neonatal - acute conjunctivitis disseminated- arthritis |
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NG pathogenesis
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invasion of epithelial cells
survival in neutrophils ag variation during infection **colonizes epithelial cells mediated by adhesive fimbrae Ag variation associated with DNA rearrangement** |
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NG pathogenesis
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PID = bacteria release peptidoglycan fragments toxic to ciliary epithelial cells
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NG dx/tx
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gram stain, culture from exudate
do a ligase chain reaction combo therapy for chlamydia freq transmitted by ASYMPTOMATIC women high incidence in urban heterosexual black men |
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Neisseria meningitidis
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gram (-) diplococci
microaerophilic transient component of nasal flora |
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NM diseases
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meningococcemia
1. acute onset of fever 2. rash 3. fulminant M *rapid progression, shock *purpuric, hemorrhagic lesions meningitis 1. same as bacterial meningitis 2. overall mortality 5-15% even with therapy |
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NM pathogenesis
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antiphagocytic poly capsule
*serotypes A, B, C , W135, Y * B is identical to Ecoli K1 -non-immunogenic endotoxin mediated effects *sepsis *released from cell surface |
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NM dx, tx, epi
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gram stain of CSF
culture from blood or CSF AB therapy HIGHEST incidence in 6 month to 2 year old 14-20 at risk COLLEGE FRESHMEN |
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NM prevention
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Vaccine
*purified polysaccharides against all serotypes EXCEPT B -not effective in under 2 conjugate vaccine against all but serotype B *immunization of all over 11 now recommended antibiotic prophylaxis |
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Bacterial Meningitis Etiologies
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Neonate
1. e. coli k1 2. group B strep 3. listeria monocytogenes infants (6mo to 2yr) 1. neisseria meningitis 2. streptococcus pneumoniae 3. haemophilus influenzae (essentially eliminated in US) young adult 1. neisseria meningitis |
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BM prevention
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vaccines
h. influenzae n. meningitidid s. pneumoniae |
