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36 Cards in this Set

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Anxiolytics

Benzodiazepines "zepam", "zolam", Chlordiazepoxide (Librium), Chlorazepate (Tranxene)

Non-Benzodiazepine Buspirone (Buspar)

General Side Effect of Anxiolytics

Drowsiness

What needs to be monitored in a patient taking Chlordiazepoxide Librium?

Bilirubin

What delays absorption of Chlorazepate Tranxene?

Antacids

What do you monitor in a patient taking Diazepam Valium?

Phenytoin and Levodopa Levels

What do you monitor in a patient taking Clonazepam Klonopin?

Renal and Liver Enzymes

Lower Doses of Anxiolytics should be considered for?

Elderly

What is restricted on patient's taking MAO Inhibitors?

Tyramine

What happens on stoppage of Benzodiazepines after 3-4 months of daily use?

Withdrawal Symptoms:
>> Insomnia


>> Irritability
>> Nervousnes
>> Dry Mouth
>> Tremors
>> Convulsions
>> Confusion

Antidepressants

Tricyclic Antidepressants
"tryptiline", "mine/franil", "pin"

Monoamine Oxidase Inhibitors
Parnate, Marplan, Nardil

Selective Serotonin Reuptake Inhibitors
"xetine, "pram", "ine"

Common S/E of Amitryptyline Elavil, Clomipramine Anafranil, Doxepin Sinequan, Imipramine Tofranil

Orthostatic hypotension

>give at bedtime to decrease risk

General Contraindication of Tricyclic Antidepressants

Acute MI

TCAs block reuptake of what neurotransmitter?

Epinephrine

Which type of antidepressant decreases sexual drive?

SSRIs

>Give Gingko Biloba

Antidepressants generally raise which Neurotransmitter?

Serotonin

MAOI + Tyramine= ?

Hypertensive Crisis

MAOI +MAOI = ?

Seizure

MAOI + SSRI = ?

Serotonin Syndrome

Mood elevation from Antidepressants usually take how many days?

7-28 days up to 6-8 weeks

If the patient forgets a once-a-day dose?

take the dose within 3 hours otherwise, wait for the next day.

DOSAGE SHOULD NEVER BE DOUBLED
No sudden stopping of TCAs

Hypertensive Crisis is also known as

Parnate-Cheese Reaction

Most Critical Adverse effect of MAOIs?

Orthostatic Hypotension
>10 % in elderlies

Signs/Symptoms of Hypertensive Crisis?

>> Severe headache
>> Stiff, sore neck
>> Flushing, cold, clammy skin
>> Tachycardia
>>N/V

Management of Hypertensive crisis?

>> 5 mg Phentolamine (Regitine)
>> Oral Chlorpromazine
>> Nifedipine 10 mg Sublingual

When should Fluoxetine Prozac be given

AM (second dose at noon if applicable) to avoid insomnia

SSRI drug whose absorption is not affected by food

Citalopram (Celexa)

Mood Stabilizing Drugs

Lithium
Divalproex/Valproic Acid Depakote
Lamotrigine Lamictal


Carbamazepine Tegretol

Lithium Therapeutic and Toxic levels?

Therapeutic: 0.8-1.4
Toxic: 1.5-2.0

Lithium Initial Dose and Maintenance?

600 mg, 300 mg respectively

Antipsychotics

Typical (old)
Haldol, Stelazine, Prolixin, Navane, Thorazine, Taractan, Mellaril, Serentil.

Atypical (new)
Clozaril, Risperdal, Zyprexa, Seroquel, Geodon, Abilify

Antipsychotics increase what neurotransmitter?

Dopamine

Common Side Effect of Atypical Antipsychotics?

>Metabolic Abnormalities (glucose dysregulation and hypercholesterolemia)
> Weight Gain

Common Side Effects of Typical Antipsychotics?

EPS (Haloperidol- low sedative property; used in elderly) and NMS (Stelazine)

Thorazine Adverse effects?

Photosensitivity (avoid sun exposure), highest sedation and hypotension effects

EPS?

Pseudoparkinsonism, Akathisia, Dystonia (lockjaw, torticollis), Tardive Dyskinesia (lip smackin, tongue protrusion)

Treatment: Cogentin, Benadryl, Artane

NMS

Potentially fatal.
Hyperthermia, extremenly rigid muscles, altered consciousness

Treatment: Dantrolene, Amantadine, Bromocriptine, ECT