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100 Cards in this Set

  • Front
  • Back

1) Which of the following is the MOST likely explanation for when two days after removal of a cancerous neck lesion, there is thigh and calf cramps, tingling around the lips, low serum calcium, and high serum phosphate?

A.
Hyperparathyroidism

B.
Primary hypoparathyroidism

C.
Pseudohypoparathyroidism

D.
Renal failure

E.
Vitamin D deficiency

B
2) At what level in the skin do bullae MOST likely develop in a localized cutaneous infection around the mouth with phage group II Staphylococcus aureus?

A.
Across the basal cells

B.
Below the basement membrane

C.
Between the basal cells and the basement membrane

D.
High in the epidermis

E.
Just above the basal cells
D
3) Which of the following cell types show abnormal function when there is a history in a young adult of multiple arm and leg fractures following minor falls, with a slight weakness of facial muscles on the left, mild anemia, and with generalized bony widening with partial obliteration of marrow spaces?

A.
Granulocytic stem cells

B.
Megakaryocytes

C.
Plasma cells

D.
Osteoblasts

E.
Osteoclasts
E
4) What of the following is characterized by left lower quadrant periumbilical pain in an elderly person, with the presence of fever, tender abdomen, leukocytosis, nausea, and vomiting?

A.
Acute appendicitis

B.
Diverticulitis

C.
Gallstones

D.
Pancreatitis

E.
Pyelonephritis
B
5) Which of the following genetic conditions is MOST likely to be the cause of a child born with with a small head, small eyes, six fingers on each hand, and congenital heart defects?

A.
Trisomy 13

B.
Trisomy 18

C.
Trisomy 21

D.
XXY

E.
XYY
A
6) If a woman 22 weeks pregnant has ankle edema and proteinuria, the presence of which of the following would determine if she has preeclampsia?

A.
Diabetes mellitus

B.
Hyperuricemia

C.
Hypertension

D.
Systemic lupus erythematosus

E.
Thrombocytopenia
C
7) Which of the following blood components can be expected to increase with disseminated intravascular coagulation?

A.
Factor V

B.
Fibrin degradation products

C.
Fibrinogen

D.
Plasminogen

E.
Platelets
B
8) Which of the following additional clinical findings would MOST be associated with a woman who has oral mucosal swelling, xerostomia, and intense salivary gland destructive inflammation, as well as antibodies against ribonucleoprotein?

A.
Conjunctivitis

B.
Goiter

C.
Hemolytic anemia

D.
Proximal muscle weakness
A
9) What phenomenon is responsible when a person sets off the metal detector at the airport, despite removing watch, belt buckle, and every other obvious source of metal?

A.
Argyria

B.
Gall stones

C.
Hemochromatosis

D.
Kidney stones

E.
Wilson's disease
C
10) Which of the following is the explanation for the laboratory findings in an alcoholic with chronic obstructive lung disease, secondary to cigarette smoking, of persistently lower serum levels than expected of theophylline which is being used as a bronchodilator, even though the drug is taken according to schedule?

A.
Cirrhosis of the liver

B.
Decreased absorption

C.
Enhanced liver metabolism

D.
Increased urinary clearance

E.
Noncompliance
C
11) Which of the following could develop with a mucosal neuroma on the lower lip, family history of medullary thyroid carcinoma, and recent introduction of severe headaches, perspiration, palpitations, and hypertension?

A.
Gastrinoma

B.
Insulinoma

C.
Parathyroid adenoma

D.
Pheochromocytoma

E.
Pituitary adenoma
D
12) Which of the following substances is significantly elevated in the serum of a young adult male with bilateral parotid gland swelling, orchitis, and fever and malaise?

A.
Alanine aminotransferase

B.
Amylase

C.
Aspartate aminotransferase

D.
Cortisol

E.
Creatine phosphokinase, MB isoenzyme
B
13) Which of the following forms of gastritis would MOST likely be found with a history of long-term use of nonsteroidal antiinflammatory drugs and complaints of heartburn, nausea, and vomiting for several days?

A.
Acute gastritis

B.
Chronic antral gastritis

C.
Chronic fundal gastritis

D.
Hypertrophic gastritis

E.
Lymphocytic gastritis
A
14) What is responsible for mild temporary hyperthyroidism after a person complains of a severe sore throat?

A.
Diffuse nontoxic goiter

B.
Grave's disease

C.
Hashimoto's thyroiditis

D.
Subacute granulomatous thyroiditis
D
15) What reaction has occured if after receiving a tuberculosis vaccine, the area becomes indurated and erythematous, having a 12 mm diameter?

A.
Antibody-dependent cell-mediated cytotoxicity

B.
Local anaphylaxis

C.
T-cell mediated cytotoxicity

D.
Type III hypersensitivity

E.
Type IV hypersensitivity
E
16) Which of the following is characterized by extreme weakness, fatigue, nausea, stomach cramps, hypotensive while sitting and even more on standing, hyperkalemia, increased freckling around the eyes, and darkening of the palmar creases?

A.
Addison's disease

B.
Conn's syndrome

C.
Cushing's syndrome

D.
Secondary adrenal insufficiency

E.
Tertiary adrenal insufficiency
A
17) A 45-year-old man presents to a physician with back pain, facial pain, coarse facial features, and kyphosis. His laboratory studies show elevated alkaline phosphatase. X-ray studies demonstrate skull thickening with narrowing of foramina and bowing of the femur and tibia. Bone biopsy reveals a mosaic pattern of bone spicules with prominent osteoid seams. Which of the following neoplasms occurs at an increased frequency in patients with this disorder?

A.
Astrocytoma

B.
Hodgkin lymphoma

C.
Meningioma

D.
Non-Hodgkin lymphoma

E.
Osteosarcoma
A
18) Which of the following can be present with swollen and painful toes and knees, morning low back stiffness, conjunctivitis, as well as mouth and skin ulcerations in a young adult?

A.
Gout

B.
Lyme disease

C.
Reiter's syndrome

D.
Rheumatoid arthritis

E.
Septic arthritis
C
19) Which of the following antigens would autoantibodies be directed against when there is symmetrical swelling of the proximal phalangeal joints and large subcutaneous nodules over the extensor surfaces of both arms of a older woman?

A.
Acetylcholine receptor

B.
Double stranded DNA

C.
Histones

D.
IgG

E.
Ribonucleoprotein
D
20) What is the BEST explanation for rapid weight gain, buffalo hump formation, prominent vertical purple abdominal striae, and the increase of fasting blood glucose, plasma levels of ACTH and cortisol, and also the presence of osteoporosis, hypertension, poor wound healing, and hypokalemia in an older male?

A.
Addison's disease

B.
An ectopic ACTH-secreting tumor

C.
Conn's syndrome

D.
Cushing's disease

E.
Primary hypercortisolism
D
21) What condition is marked by dilated cardiomyopathy, slow speech and intellectual function, fatigue, lethargy, cold intolerance, listlessness, thickened facial features, periorbital edema, dry, coarse skin, and peripheral edema, and also with low serum levels of T4 and high ones of TSH?

A.
Cretinism

B.
Grave's disease

C.
Hyperthyroidism

D.
Myxedema

E.
Thyroid cancer
D
22) Which of the following occurs after an upper respiratory infection and involves severe lower back pain, generalized muscle weakness, and distal paresthesia and demyelination, but there is no appreciable sensory loss and there is minimal residual sequelae?

A.
Creutzfeldt-Jakob disease

B.
Friedreich ataxia

C.
Huntington's disease

D.
Multiple sclerosis
D
23) Which of the following can involve lassitude, myalgia, mylar rash, joint pain, elevated urinary protein, with the blood showing leukopenia and a high titer of antinuclear antibodies?

A.
Generalized fatigue

B.
Goodpasture's syndrome

C.
Systemic lupus erythematosus

D.
Scleroderma
C
24) Which of the following cancers may develop when there are islands of red tissue noted above the gastroesophageal junction in situations involving chronic reflux of gastric contents into the esophagus?

A.
Adenocarcinoma of the esophagus

B.
Adenocarcinoma of the stomach

C.
Sarcoma of the esophagus

D.
Sarcoma of the stomach

E.
Squamous cell carcinoma of the esophagus
A
25) Which of the following when removed from the diet will help improve a history of weight loss, diarrhea, flatulence, greasy stools, and increased fecal fat and marked atrophy of villi?

A.
Beef

B.
Eggs

C.
Potatoes

D.
Tomatoes

E.
Wheat
E
26) Which of the following is the MOST likely explanation for a rash in a leukemic patient that consists of multiple erythematous patches on the arms, legs, palms, and soles, some of which show central clearing and surrounding ring formation?

A.
Urticaria

B.
Erythema multiforme

C.
Kaposi's sarcoma

D.
Psoriasis
B
27) A 72-year-old man with a significant smoking history presents with dyspnea, facial erythema, and facial, truncal, and arm edema with prominence of thoracic and neck veins. Chest x-ray reveals a mass in the right mediastinum with adenopathy. Which of the following is the most likely diagnosis?

A.
Adenocarcinoma

B.
Hodgkin lymphoma

C.
Large cell carcinoma

D.
Non-small cell carcinoma

E.
Small cell carcinoma
E
28) What can be present when there is digital clubbing and tenderness over the distal ends of the radius, ulna, and fibula?

A.
Gastrointestinal cancer

B.
Liver cancer

C.
Lung cancer

D.
Renal cancer

E.
Testicular cancer
C
29) Which of the following lesions are present in an adult with newly diagnosed tuberculosis?

A.
A single lesion in a lung apex

B.
A single lesion in the gastrointestinal tract

C.
A single lesion subjacent to the pleura

D.
A lesion subjacent to the pleura in the lower part of an upper lobe and active disease in the mediastinal lymph nodes

E.
Multiple tiny masses throughout the body
A
30) Which of the following is involved when there is excessive bleeding after labor, and the laboratory studies demonstrate decreased platelets, prolonged prothrombin time and partial thromboplastin time, and increased fibrin split products?

A.
Disseminated intravascular coagulation

B.
Hemophilia A

C.
Severe liver disease

D.
Vitamin K deficiency

E.
Von Willebrand's disease
A
31) Which of the following can account for a child developing fever, conjunctivitis, photophobia, cough, white spots on a bright red background on the buccal mucosa, and a rash that begins around the hairline, then spreads to the trunk and extremities?

A.
Aphthous ulcers

B.
Herpetic stomatitis

C.
Laryngeal papillomas

D.
Measles

E.
Oral thrush
D
32) What is present when an elderly person can no longer recognize people and common objects, plan activities, and wanders with an absent look on their face, but who is still happy, yet frustrated by the memory loss, and speech is limited to simple two- or three-word sentences?

A.
Alzheimer's disease

B.
Amnestic disorder

C.
Clinical depression

D.
Substance-induced persisting dementia

E.
Parkinson's disease
A
33) Which of the following substances would be MOST likely be elevated due to the development of large osteoblastic bone lesions in a patient with prostate cancer?

A.
Prostatic acid phosphatase

B.
Prostate specific antigen

C.
Serum alkaline phosphatase

D.
Serum uric acid

E.
Leukocytes
C
34) Which of the following pair of hormones regulates the hormone responsible for a middle-aged man experiencing gradual coarsening of facial features, progressive protrusion of the lower jaw, and having to wear larger shoes and gloves?

A.
Dopamine and norepinephrine

B.
LH and hCG

C.
Prolactin and FSH

D.
Somatostatin and GHRH

E.
TSH and ACTH
D
35) Which of the following tissues or organs may be associated with hyperplasia and neoplastic proliferation if there is fatigue, feeling of constant coldness, diffusely enlarged and rubbery thyroid gland, while laboratory tests show low T3 and T4, high TSH, large numbers of lymphocytes of all degrees of maturation, a few abnormal follicular cells with eosinophilic granular cytoplasm, and only rare normal follicular cells?

A.
Colon

B.
Esophagus

C.
Peripheral nerve

D.
Skin

E.
Thymus
E
36) What is occuring when an esophagus is dilated, kinked, tortuous, partly filled with undigested foods, and is associated with chronic dysphagia?

A.
Achalasia

B.
Barrett's esophagus

C.
Hiatal hernia

D.
Plummer-Vinson syndrome

E.
Zenker's diverticulum
A
37) What is involved in a smoker with scant clear mucoid sputum, quiet sounding chest, hemoptysis, weight loss, detruction of alveolar septae around the respiratory bronchioles, with marked enlargement of the airspaces, and heavy deposits of anthracotic pigment?

A.
Asthma

B.
Chronic bronchitis

C.
Emphysema

D.
Pulmonary hypertension

E.
Silicosis
C
38) What presents with painful widespread erosions on the mucous membranes with friability, no well-defined borders, acantholysis, and with direct immunofluorescence demonstrate an intraepidermal band of IgG and C3?

A.
Bullous pemphigoid

B.
Dermatitis herpetiformis

C.
Herpes simplex I

D.
Herpes simplex II

E.
Pemphigus vulgaris
E
39) Which of the following thyroid diseases is most likely related to restlessness, fever, profuse sweating, marked tachycardia and tremor during labor, later developing delirium, nausea, vomiting, and abdominal pain between contractions?

A.
Follicular carcinoma

B.
Grave's disease

C.
Hashimoto's thyroiditis

D.
Hypertensive urgency

E.
Papillary carcinoma
B
40) Which of the following is the most probable etiology for a young person with acute bacterial endocarditis limited to the tricuspid valve?

A.
Congenital heart disease

B.
Illicit drug use

C.
Rheumatic fever

D.
Rheumatoid arthritis

E.
Rheumatic heart disease
B
41) What is the specific mechanism by which death is produced from breathing carbon monoxide in a closed space?

A.
Damage to the plasmalemma

B.
Decreased oxygen-carrying capacity of blood

C.
Increased calcium transport into mitochondria

D.
Poisoning of oxidative phosphorylation

E.
Rupture of lysosomes
B
42) Which of the following clinical features would be most likely to be present when thyroid function tests reveal increased TSH, decreased total T4, decreased free T4, and decreased T3 uptake?

A.
Diarrhea

B.
Heat intolerance

C.
Hyperactivity

D.
Palpitations

E.
Weight gain
E
43) Which of the following findings would be MOST consistent for a young person in a coma having an acetone-like odor?

A.
Alcohol intoxication

B.
Diabetic hyperosmolar coma

C.
Diabetic ketoacidosis

D.
Heroin overdose

E.
Profound hypoglycemia
C
44) A 24-year-old man presents with complaints of itching on his arms and face. He states that he took four 500-mg capsules of amoxicillin 1 hour before a dental procedure. Physical examination reveals well circumscribed wheals with raised, erythematous borders and blanched centers. Which form of hypersensitivity is this patient probably exhibiting?

A.
Acute serum sickness (Type III)

B.
Antibody-dependent cell-mediated cytotoxicity (Type II)

C.
Antireceptor antibodies (Type II)

D.
Delayed type hypersensitivity (Type IV)

E.
Immediate type hypersensitivity (Type I)
E
45) Which of the following notations in a chart indicates the greatest likelihood that a 1-cm, flat,white patch on the buccal mucosa will progress to a malignancy?

A.
Hairy leukoplakia

B.
Leukoplakia

C.
Linea alba

D.
Oral thrush

E.
Squamous papilloma
B
46) Which of the following is present in a elderly person that has thin arms and legs, a swollen abdomen, red tongue, dry, thin, and slightly yellow skin, gynecomastia, testicular atrophy, multiple spider angiomas, tremor, yellow discoloration of sclera, and short-term memory loss?

A.
Bronchogenic carcinoma

B.
Colon carcinoma

C.
Congestive heart failure

D.
Type 2 diabetes mellitus

E.
Hepatic cirrhosis
E
47) Which of the following laboratory tests is performed following a head injury so as to differentiate between nephrogenic and neurogenic diabetes insipidus?

A.
Creatinine in a 24-hour urine collection

B.
Urine osmolality after vasopressin administration

C.
Serum renin after infusion of hypotonic saline

D.
Serum sodium after infusion of hypertonic saline
B
48) Which of the following laboratory results would be expected in a child with 2 standard deviations below the expected mean height, delayed bone maturation, goiter, and a point mutation in the thyroid hormone receptor?

A.
Decreased radioactive iodine uptake test

B.
Increased plasma T4 concentration

C.
Decreased plasma TSH concentration

D.
Increased basal metabolic rate
B
49) What form of arthritis is present in an elderly woman that complains of ill-fitting dentures, dry eyes and mouth, and severe arthritic pain?

A.
Gonococcal arthritis

B.
Gouty arthritis

C.
Osteoarthritis

D.
Pseudogout

E.
Rheumatoid arthritis
E
50) A 7-year-old boy is not having any behavioral problems in school, but he is having a great deal of trouble paying attention in class. He has normal IQ and cognitive function, but occasionally asks that questions be repeated after staring blankly into space for a few seconds. Which of the following disorders most likely accounts for these symptoms?

A.
Absence seizures

B.
Attention deficit hyperactivity disorder

C.
Schizophrenia with childhood onset

D.
Parkinson disease
A
51) Which of the following hormones is most likely secreted by mass in the head of the pancreas in a person with multiple intractable gastric and duodenal peptic ulcers and marked elevation of gastric acid secretion?

A.
Calcitonin

B.
Epinephrine

C.
Gastrin

D.
Parathormone

E.
Vasoactive intestinal peptide
C
52) Which of the following findings would MOST likely also be present with a history of scleroderma that has a near absence of smooth muscle peristalsis and lower esophageal sphincter tone?

A.
Anemia

B.
Atrophic glossitis

C.
Hourglass-shaped stomach on barium swallow

D.
Massively dilated colon

E.
Muscle replaced with connective tissue
E
53) Which of the following is the MOST significant risk factor for breast cancer in a 40-year-old woman?

A.
Breast-feeding after pregnancy

B.
Caffeine consumption

C.
Cigarette smoking

D.
Family history

E.
Nulliparity
D
54) A child with cystic fibrosis may have a history of meconium ileus, chronic cough, frequent respiratory tract infections, and bulky, foul-smelling stools and _______ ?

A.
Cystinuria

B.
Hypoglycemia

C.
Iron deficiency anemia

D.
Laryngeal papillomas

E.
Pancreatic insufficiency
E
55) What are multiple long-standing tan to brownish lesions on the face and back of older individuals that are slightly raised with a rough surface,typically 0.5-1.5 cm in diameter, and that show an ability to be peeled off?

A.
Eczema

B.
Melanoma

C.
Psoriasis

D.
Seborrheic keratoses

E.
Verruca vulgaris
D
56) Which of the following laboratory findings would be MOST likely in a teenage girl with delayed puberty, short stature, webbed neck, low-set ears, fish-like mouth, and ptosis?

A.
Decreased plasma growth hormone

B.
Decreased plasma growth hormone

C.
Increased plasma follicle stimulating hormone

D.
Increased plasma inhibin

E.
Increased plasma estrogen
C
57) Which of the following presents with a painful, swollen knee, geographic tongue, and resolving psoriasiform rash on the palms and soles, as well as urethritis and conjunctivitis?

A.
Gout

B.
Bacillary arthritis

C.
Osteoarthritis

D.
Osteoporosis

E.
Rheumatoid arthritis
E
58) Which of the following can be noted in a rheumatoid arthritic that has acute caries and chronic parotid gland enlargement?

A.
Oral squamous cell carcinoma

B.
Polyarteritis nodosa

C.
Sjogren's syndrome

D.
Systemic lupus erythematosus

E.
Thyrotoxicosis
C
59) Which of the following is the cause of joint pain involving the large leg joints in a young adult accompanied by diarrhea that is often bloody?

A.
Amebic colitis

B.
Chronic appendicitis

C.
Diverticulosis

D.
Pseudomembranous colitis

E.
Ulcerative colitis
E
60) Two diabetic patients are seen by a clinician. The first patient Comparing an older person just diagnosed with diabetes that was identified by the presence of hyperglycemia and diabetes in a young person who had previously presented with polyuria and polydipsia, the younger person is more likely to:

A.
be obese

B.
become euglycemic with oral hypoglycemic agents

C.
develop ketoacidosis

D.
have relatively high endogenous insulin levels

E.
have tissue insulin insensitivity
C
61) Which of the following processes is related to a asymptomatic perimenopausal woman demonstrating bony swellings in the distal interpharyngeal joints; however no inflammation is apparent and the proximal interphalangeal joints, hands, and wrists are not involved?

A.
Autoantibody formation

B.
Bacterial infection

C.
Crystal deposition

D.
Joint trauma

E.
Viral infection
D
62) Which of the following is present with a complaint of tiredness and muscle weakness, as well as increased blood pressure, plasma sodium and plasma aldosterone, and decreased plasma potassium, hematocrit, and plasma renin activity?

A.
Addison's disease

B.
Conn's syndrome

C.
Cushing's syndrome

D.
Hypothyroidism

E.
Pheochromocytoma
B
63) Which of the following additional findings would MOST likely be present in a child with freckles all over his body, including the buccal mucosa, lips, palms, soles, and skin not exposed to sun?

A.
Colonic polyps

B.
Desmoid tumors

C.
Epidermoid cysts

D.
Osteomas of the jaw

E.
Pigmented ocular fundus
A
64) In a PPD skin test that shows >10 mm of induration, which of the following type of reactive cells would be found?

A.
B lymphocyte

B.
Eosinophil

C.
Mast cell

D.
Neutrophil

E.
T lymphocyte
E
65) Which of the following is the MAJOR chemotactic factor responsible for attracting neutrophils?

A.
C3b

B.
C5a

C.
IgM

D.
IL-2

E.
Lysozyme
B
66) Which of the following is characterized by a young boy with failure to thrive, recurrent seizures, hepatomegaly, renomegaly, severe hypoglycemia, hyperlipidemia, lactic acidosis, and ketosis?

A.
Gaucher's disease

B.
McArdle's disease

C.
Niemann-Pick disease

D.
Pompe's disease

E.
von Gierke's disease
E
67) Which of the following disorders is associated with the same oncogenic virus that is the likely cause of nonkeratinizing squamous cell carcinoma of the nose, pharynx, and sinuses?

A.
Adult T-cell leukemia

B.
Burkitt's lymphoma

C.
Cervical carcinoma

D.
Hepatocellular carcinoma

E.
Kaposi's sarcoma
B
68) What is at risk to develop when there is substernal burning pain exacerbated by large meals, cigarettes, and caffeine, and laying on the back, especially when sleeping at night, but improved with antacids?

A.
Cardiac ischemia

B.
Columnar metaplasia of the distal esophagus

C.
Mallory-Weiss lesion in the esophagus

D.
Squamous cell carcinoma

E.
Zenker's diverticulum
B
69) Which of the following in a middle-aged person can cause a persistent, long term productive cough with a past history of smoking and with the recent presence of a green sputum and fever?

A.
Bronchogenic carcinoma

B.
Chronic bronchitis with superimposed infection

C.
Cystic fibrosis

D.
Emphysema

E.
Pulmonary tuberculosis
B
70) What is noted histologically with extensive pruritic wheals following ingestion of certain seafoods?

A.
Dilated superficial lymphatic channels

B.
Granular complement and IgG at the dermal/epidermal junction

C.
Microscopic blisters

D.
Munro microabscesses

E.
Solar elastosis
A
71) Which will increase in the plasma and can cause an acid-base disorder in an uncontrolled type 1 diabetic having breath that smells like nail polish remover?

A.
Formic acid

B.
Glycolic acid

C.
Ketoacids

D.
Lactic acid

E.
Oxalic acid
C
72) A 25-year-old man experiences the gradual onset of intermittent diarrhea that over years progresses to severe diarrhea, alternating with constipation, rectal bleeding, and passage of mucus. On examination, the abdomen is tender over the colon, and stool examination fails to reveal parasites. Colonoscopy demonstrates inflammation limited to the rectum, with no higher lesions. Which of the following diseases is most consistent with this history?

A.
Celiac disease

B.
Pseudomembranous colitis

C.
Traveler's diarrhea

D.
Ulcerative colitis

E.
Whipple disease
B
73) What disease state can be present when focal calcification is found above the sella turcica, and there is visual field abnormalities and diabetes insipidus, while needle biopsy shows tissue resembling tooth enamel?

A.
Craniopharyngioma

B.
Glioblastoma multiforme

C.
Large pituitary adenoma

D.
Medulloblastoma

E.
Pituitary microadenoma
A
74) Which of the following locations listed is the more common primary site for oral squamous cell carcinoma?

A.
Ventral tongue surface

B.
Buccal mucosa

C.
Floor of mouth

D.
Palate

E.
Tip of tongue
C
75) Which of the following conditions explains the pain in the upper portion of the neck on swallowing, with regurgitation of undigested food shortly after eating?

A.
Mallory-Weiss tears

B.
Plummer-Vinson syndrome

C.
Schatzki rings

D.
Traction diverticula

E.
Zenker's diverticulum
E
76) Which of the following findings would suggest pemphigus vulgaris as opposed to bullous pemphigoid?

A.
Eosinophils within bullae

B.
Negative Nikolsky's sign

C.
IgG autoantibody activity

D.
Oral mucosal lesions
D
77) A 30-year smoker walks into clinic, breathing heavily and complaining of dyspnea and constant fatigue. On physical examination, the physician observes a "barrel chest" (expanded, with increased anteroposterior diameter) and hypertrophy of the accessory respiratory muscles. No cyanosis is evident. Occasionally he develops episodes of nonproductive cough, but he denies asthma attacks. Blood gas analysis shows minimal hypoxemia and normal CO2. Which of the following underlying pathogenetic mechanisms is most likely responsible for this patient's condition?

A.
Airway obstruction

B.
Bronchospasm

C.
Chest wall deformity

D.
Interstitial infiltration

E.
Loss of elastic recoil
E
78) What is the MOST likely cause for profuse upper gastrointestinal bleeding with hematemesis and unconsciousness in an alcholic?

A.
Barrett's esophagus

B.
Helicobacter gastritis

C.
Mallory-Weiss tear

D.
Schatzki ring

E.
Zenker's diverticulum
C
79) Which of the following clinical conditions is most likely to result in hoarseness during speech?

A.
Right lung apical segment bronchogenic carcinoma

B.
Congestive heart failure

C.
Emphysema

D.
Pulmonary thromboembolism

E.
Thymoma
A
80 ) Which of the following features characterizes apoptosis but not necrosis?

A.
Disaggregation of polyribosomes

B.
Eosinophilia

C.
Inflammation

D.
Karyolysis

E.
Peripheral aggregation of chromatin
E
81) Which of the following can occur in a child after an upper respiratory infection who starts to form multiple petechial hemorrhages and blood tests show marked reduction in platelets?

A.
Idiopathic thrombocytopenic purpura

B.
Iron deficiency anemia

C.
Pernicious anemia

D.
Von Willebrand's disease
A
82) Patients with Plummer-Vinson syndrome are at an increased risk for

A.
Adenocarcinoma of the esophagus

B.
Barrett's esophagus

C.
Candida infection

D.
Cytomegalovirus esophagitis

E.
Squamous cell carcinoma of esophagus
E
83) What is a flesh-colored lesion that presents on the nose that is 1 cm in diameter with induration and central ulceration?

A.
Basal cell carcinoma

B.
Eczema

C.
Psoriasis

D.
Urticaria

E.
Verruca vulgaris
A
84) Which of the following is may cause sudden extreme hematemesis and eventual loss of consciousness?

A.
Esophageal varices

B.
Mallory-Weiss tear

C.
Barrett's esophagus

D.
Schatzki ring

E.
Zenker's diverticulum
A
85) Which of the following characteristics is typical in the early stages of type 1 diabetes mellitus, but not the early stages of type 2 diabetes mellitus?

A.
Adult onset

B.
Nearly complete twin concordance

C.
Increased serum insulin levels

D.
Ketoacidosis

E.
Obesity
D
86) Which of the following tests should be performed on a young adult woman who presents with with fatigue, malaise, low-grade fever, arthralgias, elevated BUN, proteinuria, and butterfly rash on her face?

A.
Anticentromeric antibody

B.
Antimitochondrial antibody

C.
Antinuclear antibody

D.
Anti-TSH receptor antibody

E.
Rheumatoid factor
C
87) Which of the following can develop in a diabetic with a long-standing intrauterine contraceptive device that develops chronic pelvic pain and whose latest endometrial biospy shows a prominent infiltrate composed of lymphocytes, plasma cells, and histiocytes?

A.
Acute endometritis

B.
Candida infection

C.
Chronic endometritis

D.
Endometriosis

E.
Simple hyperplasia of endometrium
C
88) A patient has intermittent diarrhea and abdominal pain and begins to pass fecal material in his urine. Which of the following diseases is most likely to cause this complication?

A.
Celiac disease

B.
Crohn disease

C.
Diverticulitis

D.
Pseudomembranous colitis

E.
Ulcerative colitis
B
89) A patient has intermittent diarrhea and abdominal pain and begins to pass fecal material in his urine. Which of the following diseases is most likely to cause this complication?

A.
Celiac disease

B.
Crohn disease

C.
Diverticulitis

D.
Pseudomembranous colitis

E.
Ulcerative colitis
B
90) Arthritis with a history significant for morning stiffness and symmetric deformities of the affected joints is most likely associated with which condition?

A.
Ankylosing spondylitis

B.
Gouty arthritis

C.
Osteoarthritis

D.
Rheumatoid arthritis

E.
Septic arthritis
D
91) Which of the following can predispose a women to have vaginal itchiness and white curdy discharge that upon microscopic examination demonstrates fungal hyphae and yeast forms? W

A.
Crohn's disease

B.
Diabetes mellitus

C.
Disseminated gonococcal infection

D.
Rheumatoid arthritis

E.
Systemic lupus erythematosus
B
92) Which of the following most likely precedes the development of non-Hodgkin's lymphoma in the gland?

A.
Follicular thyroid carcinoma

B.
Grave's disease

C.
Hashimoto's thyroiditis

D.
Nodular goiter

E.
Papillary thyroid carcinoma
C
93) Which of the following most likely describes a person who is pleasant, emotionally warm and happy, lives at home, works in a sheltered workshop, did not complete high school, and talks in three-word sentences?

A.
Autistic disorder

B.
Mental depression

C.
Mental retardation

D.
Mixed receptive-expressive language disorder

E.
Parkinson's disease
C
94) If polydipsia and polyuria are present, but without glycosuria, which of the following should be considered?

A.
Addison's disease

B.
Diabetes insipidus

C.
Diabetes mellitus

D.
Grave's disease
B
95) Microscopically, which of following do the proliferating cells in Kaposi's sarcoma associated with HIV infection MOST closely resemble? M

A.
Angiosarcoma

B.
Carcinosarcoma

C.
Lymphoma

D.
Malignant fibrous histiocytoma

E.
Melanoma
A
96) What is the cause for the anemia that develops in a person with systemic lupus erythematosus, chronic renal failure, and with a slightly yellow sclerae, enlarged spleen and positive Coombs test?

A.
Bone marrow aplasia

B.
Antibody directed against red blood cells

C.
Spleen sequestration

D.
Renal failure
B
97) Autoantibodies to which of the following components would most likely be found in a person who is not taking any medications but has multiple oral ulcers and flaccid skin bullae that were biopsied and showed a separation of epithelial cells above the basal layer?

A.
Epidermal basement membrane proteins

B.
Glycoprotein IIb/IIIa

C.
Intercellular junctions of epidermal cells

D.
Intrinsic factor

E.
Type IV collagen
C
98) Which of the following is the reason for a CBC with reticulocyte count that shows very low white blood cells and platelet counts, as well as having a bone marrow biopsy that demonstrates cellularity less than 25%?

A.
Anemia of chronic disease

B.
Aplastic anemia

C.
Myelodysplasia with myelofibrosis

D.
Pure red cell aplasia
B
99) Which of the following should a person be evaluated for if they have rheumatoid arthritis and suddenly develop moderate caries?

A.
Diabetes insipidus

B.
Polyarteritis nodosa

C.
Sjogren's syndrome

D.
Systemic lupus erythematosus
C
100 ) Which of the following physical findings would be the MOST reliable indicator that an older woman with shortness of breath is experiencing heart failure?

A.
A third heart sound (S3)

B.
A fourth heart sound (S4)

C.
Ascites

D.
Orthopnea

E.
Pulmonary rales
A